TL1A/TNFSF15 Trimer Protein, Human, Recombinant (His & Avi), Biotinylated

产品编号 TMPY-07145

TL1A/TNFSF15 Trimer Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 Cells. The accession number is O95150-1.

TL1A/TNFSF15 Trimer Protein, Human, Recombinant (His & Avi), Biotinylated

产品编号 TMPY-07145

TL1A/TNFSF15 Trimer Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 Cells. The accession number is O95150-1.

规格	价格	库存	数量
20 μg	¥ 2,930	期货
100 μg	¥ 6,800	期货

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产品信息

生物活性	1. Immobilized DcR3 Protein, Human, Recombinant (hFc) (Cat#TMPY-03521) at 2 μg/mL (100 μL/well) can bind TL1A/TNFSF15 Trimer Protein, Human, Recombinant (His & Avi), Biotinylated (Cat#TMPY-07145), the EC50 is 1-3 ng/mL. 2. Loaded TL1A/TNFSF15 Trimer Protein, Human, Recombinant (His & Avi), Biotinylated (Cat#TMPY-07145) on SA Biosensor, can bind DR3 Protein, Human, Recombinant (hFc) (Cat#TMPY-01751) with an affinity constant of 2.57 μM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested). 3.Immobilized Anti-TNFSF15 Antibody, human IgG1 at 2 μg/mL (100 μL/well) can bind TL1A/TNFSF15 Trimer Protein, Human, Recombinant (His & Avi), Biotinylated (Cat#TMPY-07145), the EC50 is 22.1 ng/mL(Routinely tested).
产品描述	TL1A/TNFSF15 Trimer Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 Cells. The accession number is O95150-1.
种属	Human
表达系统	HEK293 Cells
标签	N-His-Avi
蛋白编号	O95150-1
别名	VEGI192A,VEGI,TNLG1B,TL1A,TL1,MGC129935,MGC129934
蛋白构建	A DNA sequence encoding the Human TL1A / TNFSF15 (NP_005109.2) (Leu72-Leu251) was expressed with a N-terminal polyhistidine tag followed by an AVI tag.The expressed protein was biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed. This construct has a trimer design.
蛋白纯度	≥ 95% as determined by SDS-PAGE. ≥ 90% as determined by SEC-MALS.
分子量	68.51 kDa (predicted); 69.4 kDa (reducing contition, due to glycosylation); 87.3 kDa (SEC-MALS)
内毒素	< 1.0 EU per μg protein as determined by the LAL method.
缓冲液	Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
复溶方法	Please refer to the lot-specific COA.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	TL1A, also known as TNFSF15, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is specifically expressed in endothelial cells. TL1A also can be detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon. TL1A is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It mediates activation of NF-kappa-B. It also inhibits vascular endothelial growth and angiogenesis (in vitro). TL1A promotes activation of caspases and apoptosis. It is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor.

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