Bcl-2-IN-11 (compound 6) is a potent and selective inhibitor of Bcl-2 activity, exhibiting an IC50 of 0.9 nM, and demonstrates minimal inhibition against Bcl-xl (IC50 > 1000 nM). This compound is utilized in researching various cancers linked to the overexpression of Bcl-2 family proteins, primarily malignant hematologic conditions such as acute lymphoid leukemia. Importantly, Bcl-2-IN-11 minimizes the risk of toxic side effects, including thrombocytopenia [1], by sparing Bcl-xl.

BCL2:0.9 nM, BCL-XL:>1000 nM

Bcl-2-IN-11（化合物6）可有效抑制RS4;11细胞系的急性淋巴细胞增殖，其半数抑制浓度（IC50）为2.37 nM[1]。