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EGFR-IN-119 (Compound 5l) 作为一种EGFR抑制剂,拥有84.3 nM的IC50值.在A549肺癌细胞中,EGFR-IN-119展现出1.34 μM的IC50,指其具有显著的细胞毒性抑制效果.该化合物还能降低EGFR、KRAS及MAP2K基因的表达,并通过减少活性氧(ROS)级别和超极化线粒体膜电位来发挥抗氧化作用.
EGFR-IN-119 (Compound 5l) 作为一种EGFR抑制剂,拥有84.3 nM的IC50值.在A549肺癌细胞中,EGFR-IN-119展现出1.34 μM的IC50,指其具有显著的细胞毒性抑制效果.该化合物还能降低EGFR、KRAS及MAP2K基因的表达,并通过减少活性氧(ROS)级别和超极化线粒体膜电位来发挥抗氧化作用.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 期货 | |
50 mg | 询价 | 期货 |
产品描述 | EGFR-IN-119 (Compound 5l) functions as an inhibitor of EGFR with an IC50 of 84.3 nM. It exhibits cytotoxic effects in A549 lung cancer cells with an IC50 of 1.34 μM. Additionally, EGFR-IN-119 downregulates the expression of EGFR, KRAS, and MAP2K genes. It displays antioxidative activity by decreasing reactive oxygen species (ROS) and hyperpolarizing mitochondrial membrane potential. |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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