Benzthiazide

产品编号 T0782Cas号 91-33-8

别名 Aquatag|||苄噻嗪|||Lemazide|||Dihydrex

Benzthiazide (Lemazide) 是长效利尿剂及抗高血压剂。它也是碳酸酐酶 9 的抑制剂，他对 CA9，CA2 和 CA1 的 Ki 分别为 8.0，8.8 和 10 nM。它对肿瘤细胞增殖具有抑制作用。

产品编号 T0782别名 Aquatag, 苄噻嗪, Lemazide, DihydrexCas号 91-33-8

规格	价格	库存	数量
100 mg	¥ 136	现货
1 mL x 10 mM (in DMSO)	¥ 312	现货

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生物活性

产品描述	Benzthiazide (Lemazide) is used in the therapy of edema and hypertension. Like other thiazides, benzthiazide accelerates water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.
靶点活性	Carbonic anhydrase I:10 nM (Ki), CA9:8.0 nM (Ki), Carbonic anhydrase II:8.8 nM (Ki)
别名	Aquatag, 苄噻嗪, Lemazide, Dihydrex

化学信息

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 45 mg/mL (104.19 mM)

溶液配制表

DMSO