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Meprin alpha/MEP1A Protein, Human, Recombinant (His)

产品编号 TMPY-01737

别名: meprin A, α (PABA peptide hydrolase), meprin A, alpha (PABA peptide hydrolase), Meprin α/MEP1A, PPHA

Meprin alpha/MEP1A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 67.7 kDa and the accession number is Q16819.

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Meprin alpha/MEP1A Protein, Human, Recombinant (His)

规格	价格/CNY		货期	数量
50 μg	￥ 3,820		5日内发货

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生物活性	Testing in progress
产品描述	Meprin alpha/MEP1A Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 67.7 kDa and the accession number is Q16819.

种属	Human
表达系统	HEK293 Cells
标签	C-His
蛋白编号	Q16819
别名	meprin A, α (PABA peptide hydrolase), meprin A, alpha (PABA peptide hydrolase), Meprin α/MEP1A, PPHA
蛋白构建	The Human MEP1A (NP_005579.2) extracellular domain (Met 1-Gln 601) was expressed, fused with a polyhistidine tag at the C-terminus.
蛋白纯度	> 90 % as determined by SDS-PAGE
分子量	67.7 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Meprin A subunit alpha, also known as MEP1A, and Endopeptidase-2, is a single-pass type I membrane protein that belongs to the peptidase M12A family. MEP1A contains one EGF-like domain, one MAM domain, and one MATH domain. Meprins are unique plasma membrane and secreted metalloproteinases that are highly regulated at the transcriptional and post-translational levels. Meprin alpha and beta subunits are abundantly expressed in kidney and intestinal epithelial cells, are secreted into the urinary tract and intestinal lumen and are found in leukocytes and cancer cells under certain conditions. Meprins are capable of proteolytically degrading extracellular matrix proteins, processing bioactive proteins, and play a role in inflammatory processes. Meprin A and B are highly regulated, secreted and cell-surface homo- and hetero-oligomeric enzymes. Meprins are abundantly expressed in the kidney and intestine. The multidomain alpha and beta subunits have high sequence identity. They have very different substrate specificities, oligomerization potentials, and are differentially regulated. Meprin A appears to be an important therapeutic target and urinary excretion appears to be a potential biomarker of acute kidney injury ( AKI ).

参考文献

1. Bertenshaw,GP. et al., 2002, Biol Chem. 383 (7-8):1175-83. 2. Bond, JS. et al., 2005, FEBS Lett. 579 (15): 3317-22. 3. Herzog, C. et al., 2007, Kidney Int. 71 (10): 1009-18. 4. Yura, RE. et al., 2009, Am J Physiol Renal Physiol. 296 (1): F135-44.

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Keywords

Meprin alpha/MEP1A Protein, Human, Recombinant (His) PABA peptide hydrolase meprin A, α (PABA peptide hydrolase) meprin A, alpha (PABA peptide hydrolase) meprin A, alpha Meprin α/MEP1A PPHA recombinant recombinant-proteins proteins protein

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