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SCN3B Protein, Human, Recombinant (His)

产品编号 TMPY-02976

别名: ATFB16, HSA243396, BRGDA7, SCNB3, sodium channel, voltage gated, type III β subunit, sodium channel, voltage gated, type III beta subunit

SCN3B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.2 kDa and the accession number is Q9NY72.

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SCN3B Protein, Human, Recombinant (His)

规格	价格/CNY		货期	数量
100 μg	￥ 4,460		5日内发货

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生物活性	Testing in progress
产品描述	SCN3B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.2 kDa and the accession number is Q9NY72.

种属	Human
表达系统	HEK293 Cells
标签	C-His
蛋白编号	Q9NY72
别名	ATFB16, HSA243396, BRGDA7, SCNB3, sodium channel, voltage gated, type III β subunit, sodium channel, voltage gated, type III beta subunit
蛋白构建	The mature form of Human SCN3B (Q9NY72) extracellular domain (Met1-Glu159) was expressed with a polyhistidine tag at the C-terminus.
蛋白纯度	> 95 % as determined by SDS-PAGE
分子量	17.2 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	SCN3B (sodium channel, voltage-gated, type III, beta, human IgG1-Fc chimera) belongs to the sodium channel auxiliary subunit SCN3B family. It contains 1 Ig-like C2-type (immunoglobulin-like) domain. Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. SCN3B gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified. Defects in SCN3B are the cause of Brugada syndrome type 7. A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram. It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs (called ventricular fibrillation), the individual will faint and may die in a few minutes if the heart is not reset.

参考文献

1. Morgan K,et al.(2000) _3: An additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics. Proc Natl Acad Sci. 97(5):2308-13. 2. Hartley JL,et al.(2001) DNA Cloning Using In Vitro Site-Specific Recombination. Genome Res. 10(11): 1788-95. 3. Hirosawa M,et al.(2000) Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. DNA Res. 6(5):329-36.

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Keywords

SCN3B Protein, Human, Recombinant (His) HSA-243396 ATFB-16 BRGDA-7 ATFB16 HSA243396 HSA 243396 SCNB-3 SCNB 3 ATFB 16 BRGDA7 SCNB3 sodium channel, voltage gated, type III β subunit sodium channel, voltage gated, type III b subunit sodium channel, voltage gated, type III beta subunit BRGDA 7 recombinant recombinant-proteins proteins protein

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