Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signaling pathway. Gliotoxin is a mycotoxin produced by several moulds such as Aspergillus fumigatus. Gliotoxin activates PKA and increases intracellular cAMP concentration and inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis.

Mycobacterium tuberculosis:<0.03 μM(MIC50)

这些化合物（1-12）的结构主要通过广泛的NMR、ESIMS光谱数据以及与先前描述的化合物比较来确定。此外，这些化合物的抗结核、细胞毒性、抗菌、COX-2抑制和抗病毒活性已进行了评估[1]。