PROTAC BRD4 Degrader-15

Name: PROTAC BRD4 Degrader-15
Brand: TargetMol
SKU: T40074
Price: 298 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T40074Cas号 2417370-67-1

别名 PROTAC BRD4 Degrader-15

PROTAC BRD4 Degrader-15 is a chemical compound consisting of a PROteolysis TArgeting Chimera (PROTAC) linked to ligands specific to von Hippel-Lindau and BRD4. It exhibits an IC50 of 7.2 nM for BRD4 BD1 and 8.1 nM for BRD4 BD2. Additionally, PROTAC BRD4 Degrader-15 demonstrates potent degradation activity against the BRD4 protein in PC3 prostate cancer cells.

PROTAC BRD4 Degrader-15

还可以

产品编号 T40074 别名 PROTAC BRD4 Degrader-15Cas号 2417370-67-1

规格	价格	库存	数量
100 mg	询价	期货
500 mg	询价	期货

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生物活性

产品描述	PROTAC BRD4 Degrader-15 is a chemical compound consisting of a PROteolysis TArgeting Chimera (PROTAC) linked to ligands specific to von Hippel-Lindau and BRD4. It exhibits an IC50 of 7.2 nM for BRD4 BD1 and 8.1 nM for BRD4 BD2. Additionally, PROTAC BRD4 Degrader-15 demonstrates potent degradation activity against the BRD4 protein in PC3 prostate cancer cells.
靶点活性	BRD4 BD2:8.1 nM (IC50), BRD4 BD1:7.2 nM (IC50)
体外活性	PROTAC BRD4 Degrader-15 (compound 13) (4 h) inhibits suppresses MYC gene transcript in MV4-11 AML cells, with an IC 50 of 15 nM[1]. PROTAC BRD4 Degrader-15 (6 days) inhibits the proliferation of HL-60 and PC3-S1 cells, with an IC 50 of 4.2 nM and 91 nM[1].
别名	PROTAC BRD4 Degrader-15