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ZW-1226 作为一种选择性MRP1抑制剂,在 5 μM浓度时能减少MRP1囊泡的摄取活性65%.此化合物通过GSH依赖机制来抑制MRP1,同时相比其他主要ABC转运蛋白(如P-gp、BCRP、MRP2和MRP3),展示出对MRP1的高选择性.
ZW-1226 作为一种选择性MRP1抑制剂,在 5 μM浓度时能减少MRP1囊泡的摄取活性65%.此化合物通过GSH依赖机制来抑制MRP1,同时相比其他主要ABC转运蛋白(如P-gp、BCRP、MRP2和MRP3),展示出对MRP1的高选择性.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | ZW-1226 is a selective MRP1 inhibitor that reduces the uptake activity of MRP1 vesicles by 65% at a concentration of 5 μM. It inhibits MRP1 in a GSH-dependent manner and exhibits considerable selectivity towards MRP1 over other primary ABC transport proteins (including P-gp, BCRP, MRP2, and MRP3). |
分子量 | 420.42 |
分子式 | C25H16N4O3 |
CAS No. | 2351940-23-1 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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