CX3CR1 Protein-VLP, Human, Recombinant (Flag & Strep) is expressed in HEK293 Cells. The accession number is P49238.

Human

HEK293 Cells

A DNA sequence encoding the Human CX3CR1-VLP (P49238) (Met1-Leu315,thermostabilizing mutations) was expressed, with a Flag tag at the N-terminus, and a strep tag at the C-terminus.

Samples are stable for up to twelve months from date of receipt at -70℃. Store it under sterile conditions at -70℃ or lower. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

The CX3C chemokine axis consists of fractalkine (CX3CL1) and its receptor (CX3CR1); these are expressed by neurons and microglia respectively, and are known to modulate microglial activation. Neuronal Cx3cr1 may impact Alzheimer's disease-like pathology by modulating conformational state-dependent amyloid-beta-induced synaptotoxicity. Microglial cells participate in brain development and influence neuronal loss and synaptic maturation. Fractalkine is an important neuronal chemokine whose expression increases during development and that can influence microglia function via the fractalkine receptor, CX3CR1. Mice lacking Cx3cr1 show a variety of neuronal defects thought to be the result of deficient microglia function. Knockout of the microglial chemokine receptor Cx3cr1 to prevent neuron loss.