Chlorobutanol hemihydrate (Chlorbutol hemihydrate) is an orally toxic preservative with antimicrobial activity that inhibits Gram-positive and Gram-negative bacteria and fungi, inhibits the aggregation and release of human platelets in vitro, and is commonly used in cosmetics.

通过灌胃口服，在为期 28 天的重复剂量毒性研究中，高剂量设定为 100 mg/kg/day，中剂量、中低剂量和低剂量分别设定为 50 mg/kg/day、25 mg/kg/day和 12.5 mg/kg/day。在重复剂量毒性研究中，体重没有明显变化。100 mg/kg/day剂量组的雌雄动物肝脏和肾脏的相对重量都明显增加。[1]