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MyoMed-205 是一种MuRF1(肌肉环指蛋白1) 活性抑制剂。它可以防止单侧膈神经去神经12小时后引起的早期膈肌收缩功能障碍和萎缩。通过抑制MuRF1活性,MyoMed-205 减少了肌肉蛋白的泛素化和后续的蛋白酶体降解。此外,MyoMed-205 能提高磷酸化Akt(ser473)的蛋白水平,Akt对肌肉的生长和维持至关重要。MyoMed-205 适用于研究和治疗由早期失用引起的膈肌功能障碍和萎缩(DIDD),尤其是在膈肌麻痹或机械通气等临床情况下。
MyoMed-205 是一种MuRF1(肌肉环指蛋白1) 活性抑制剂。它可以防止单侧膈神经去神经12小时后引起的早期膈肌收缩功能障碍和萎缩。通过抑制MuRF1活性,MyoMed-205 减少了肌肉蛋白的泛素化和后续的蛋白酶体降解。此外,MyoMed-205 能提高磷酸化Akt(ser473)的蛋白水平,Akt对肌肉的生长和维持至关重要。MyoMed-205 适用于研究和治疗由早期失用引起的膈肌功能障碍和萎缩(DIDD),尤其是在膈肌麻痹或机械通气等临床情况下。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | MyoMed-205 is an inhibitor of MuRF1 (muscle ring finger protein 1) activity. It effectively prevents early diaphragm contractile dysfunction and atrophy following 12 hours of unilateral phrenic nerve denervation. By inhibiting MuRF1, MyoMed-205 reduces muscle protein ubiquitination and subsequent proteasome degradation. It also increases the protein levels of phosphorylated Akt (ser473), an essential signaling molecule for muscle growth and maintenance. MyoMed-205 is applicable in the research and treatment of diaphragm dysfunction and atrophy (DIDD) due to early disuse, particularly in clinical situations such as diaphragm paralysis or mechanical ventilation. |
分子量 | 491.56 |
分子式 | C26H25N3O5S |
CAS No. | 2614161-13-4 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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