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4-oxo Docosahexaenoic Acid
还可以产品编号 T36868Cas号 845673-74-7
4-oxo Docosahexaenoic acid (4-oxo DHA) is a putative metabolite of DHA with antiproliferative and PPARγ agonist activity. It inhibits the growth of several triple negative breast cancer cell lines (MCF-10F, trMCF, bsMCF, MDA-MB-231, and BT549) at 50-100 μM, however it increased proliferation of MCF-7 cells. 4-oxo DHA binds covalently to PPARγ and activates gene transcription in luciferase reporter assays and in dendritic cells with EC50 values of approximately 8-16 μM.
4-oxo Docosahexaenoic Acid
还可以产品编号 T36868Cas号 845673-74-7
4-oxo Docosahexaenoic acid (4-oxo DHA) is a putative metabolite of DHA with antiproliferative and PPARγ agonist activity. It inhibits the growth of several triple negative breast cancer cell lines (MCF-10F, trMCF, bsMCF, MDA-MB-231, and BT549) at 50-100 μM, however it increased proliferation of MCF-7 cells. 4-oxo DHA binds covalently to PPARγ and activates gene transcription in luciferase reporter assays and in dendritic cells with EC50 values of approximately 8-16 μM.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 μg | 询价 | 35日内发货 | |
| 50 μg | 询价 | 35日内发货 | |
| 100 μg | 询价 | 35日内发货 | |
| 250 μg | 询价 | 35日内发货 |
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| 产品描述 | 4-oxo Docosahexaenoic acid (4-oxo DHA) is a putative metabolite of DHA with antiproliferative and PPARγ agonist activity. It inhibits the growth of several triple negative breast cancer cell lines (MCF-10F, trMCF, bsMCF, MDA-MB-231, and BT549) at 50-100 μM, however it increased proliferation of MCF-7 cells. 4-oxo DHA binds covalently to PPARγ and activates gene transcription in luciferase reporter assays and in dendritic cells with EC50 values of approximately 8-16 μM. |
| 分子量 | 342.479 |
| 分子式 | C22H30O3 |
| CAS No. | 845673-74-7 |
| 密度 | 0.992 g/cm3 (Predicted) |
储存&溶解度
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度信息 | PBS (pH 7.2): 0.1 mg/mL (0.29 mM), Sonication is recommended. DMF: 50 mg/mL (145.99 mM), Sonication is recommended. DMSO: 50 mg/mL (145.99 mM), Sonication is recommended. Ethanol: 50 mg/mL (145.99 mM), Sonication is recommended. |
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