HIV-1inhibitor-79 (Compound 3k) is an HIV inhibitor that demonstrates significant inhibitory activity against HIV-1 and its common mutants, with IC50 values of 1.9 nM for HIV-1, K103, 8.7 nM for L100I, and 11 nM for E138K. It exhibits low cytotoxicity and a high selectivity index (CC50 = 21.95 μM, SI = 11478). Additionally, HIV-1inhibitor-79 shows antiviral activity against HIV-2, with an EC50 value of 6.14 μM, and effectively inhibits HIV-1 reverse transcriptase with an IC50 of 25 nM.