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Tau-aggregation and neuroinflammation-IN-1 是一种有效的 Tau 蛋白聚集体抑制剂, 对 AcPHF6 和全长 tau 蛋白聚集体显示出显著的抑制活性。Tau-aggregation and neuroinflammation-IN-1具有抗炎活性且可减少 NO 释放。Tau-aggregation and neuroinflammation-IN-1 对 LSP 刺激的 BV2 细胞具有低细胞毒性。Tau-aggregation and neuroinflammation-IN-1 可逆转冈田酸诱导的大鼠记忆障碍。
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Tau-aggregation and neuroinflammation-IN-1 是一种有效的 Tau 蛋白聚集体抑制剂, 对 AcPHF6 和全长 tau 蛋白聚集体显示出显著的抑制活性。Tau-aggregation and neuroinflammation-IN-1具有抗炎活性且可减少 NO 释放。Tau-aggregation and neuroinflammation-IN-1 对 LSP 刺激的 BV2 细胞具有低细胞毒性。Tau-aggregation and neuroinflammation-IN-1 可逆转冈田酸诱导的大鼠记忆障碍。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 185 | 现货 | |
5 mg | ¥ 413 | 现货 | |
10 mg | ¥ 663 | 现货 | |
25 mg | ¥ 1,230 | 现货 | |
50 mg | ¥ 1,990 | 现货 | |
100 mg | ¥ 2,970 | 现货 | |
500 mg | ¥ 6,680 | 现货 |
产品描述 | Tau-aggregation and neuroinflammation-IN-1 is a potent inhibitor of tau protein aggregates, showing significant inhibitory activity against AcPHF6 and full-length tau protein aggregates. Tau-aggregation and neuroinflammation-IN-1 has anti-inflammatory activity and reduces NO release.Tau-aggregation and neuroinflammation-IN-1 has low cytotoxicity against LSP-stimulated BV2 cells.Tau-aggregation and neuroinflammation-IN-1 reverses okadaic acid-induced memory impairment in rats. |
体外活性 | Tau-aggregation及neuroinflammation-IN-1 (compound 30) (0-40 μM) 在30 μM时降低SH-SY5Y细胞的存活率。在LO2细胞中,即使在高浓度下也未显示明显的肝毒性,且在20 μM浓度下对BV2细胞的存活率无影响。[1] Tau-aggregation及neuroinflammation-IN-1(2.5、5和10 μM;24小时)在LPS刺激的BV2细胞中,保持了钠的抗炎效果,并在10 μM时降低了NO释放率41%。[1] |
体内活性 | Tau-aggregation and neuroinflammation-IN-1(5和10 mg/kg;腹腔注射;连续7天,OA注射后继续腹腔注射7天;雄性SD大鼠)显著改善了OA诱导的大鼠常规参考空间记忆和认知能力。[1] |
分子量 | 460.44 |
分子式 | C25H20N2O7 |
CAS No. | 2175953-98-5 |
Smiles | C[C@@]12C=3C(OC1=CC4=C(C2=O)C(C)=NN4C5=CC=C(C(O)=O)C=C5)=C(C(C)=O)C(O)=C(C)C3O |
存储 | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 50 mg/mL (108.59 mM), Sonication is recommended. ![]() | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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