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DI-82
还可以产品编号 T39114Cas号 1638148-50-1
DI-82 is a highly potent inhibitor of deoxycytidine kinase (dCK), displaying impressive biochemical activity with an IC50 value of 27.8 nM and a K i value of 9.2 nM. Additionally, DI-82 exhibits significant antitumor effects.
DI-82
还可以产品编号 T39114Cas号 1638148-50-1
DI-82 is a highly potent inhibitor of deoxycytidine kinase (dCK), displaying impressive biochemical activity with an IC50 value of 27.8 nM and a K i value of 9.2 nM. Additionally, DI-82 exhibits significant antitumor effects.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 2 mg | ¥ 2,490 | 5日内发货 |
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生物活性
化学信息
| 产品描述 | DI-82 is a highly potent inhibitor of deoxycytidine kinase (dCK), displaying impressive biochemical activity with an IC50 value of 27.8 nM and a K i value of 9.2 nM. Additionally, DI-82 exhibits significant antitumor effects. |
| 靶点活性 | DCK:27.8 nM (IC50app), DCK:9.2 nM (Kiapp) |
| 体外活性 | DI-82 (compound 12R) has an IC 50 of 3.7 nM in CCRF-CEM acute lymphoblastic leukemia cells[1]. DI-82 (1 μM) has a NADPH-dependent CL int of 22.7 μL/min?mg and a NADPH-dependent T 1/2 of 102 mins in a standard microsomal liver clearance assay[1]. DI-82 (200?μM) completely blunts the ability of decitabine to bind human thymidylate synthase (TS)[2]. |
| 分子量 | 510.65 |
| 分子式 | C20H26N6O4S3 |
| CAS No. | 1638148-50-1 |
储存&溶解度
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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