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LAMTOR1 Protein, Human, Recombinant (His)

产品编号 TMPH-01996

别名: LAMTOR1, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1, Protein associated with DRMs and endosomes, Ragulator complex protein LAMTOR1, p27Kip1-releasing factor from RhoA, Lipid raft adaptor protein p18

LAMTOR1 Protein, Human, Recombinant (His) is expressed in E. coli.

TargetMol的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

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LAMTOR1 Protein, Human, Recombinant (His)

规格	价格/CNY		货期	数量
20 μg	￥ 1,800		20日内发货
100 μg	￥ 3,420		20日内发货
1 mg	￥ 14,600		20日内发货

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产品描述	LAMTOR1 Protein, Human, Recombinant (His) is expressed in E. coli.

种属	Human
表达系统	E. coli
标签	N-6xHis
蛋白编号	Q6IAA8
别名	LAMTOR1, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1, Protein associated with DRMs and endosomes, Ragulator complex protein LAMTOR1, p27Kip1-releasing factor from RhoA, Lipid raft adaptor protein p18
氨基酸序列	GCCYSSENEDSDQDREERKLLLDPSSPPTKALNGAEPNYHSLPSARTDEQALLSSILAKTASNIIDVSAADSQGMEQHEYMDRARQYSTRLAVLSSSLTHWKKLPPLPSLTSQPHQVLASEPIPFSDLQQVSRIAAYAYSALSQIRVDAKEELVVQFGIP
蛋白构建	2-161 aa
蛋白纯度	> 90% as determined by SDS-PAGE.
分子量	21.7 kDa (predicted)

缓冲液	Tris-based buffer, 50% glycerol
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. LAMTOR1 is directly responsible for anchoring the Ragulator complex to membranes. Also required for late endosomes/lysosomes biogenesis it may regulate both the recycling of receptors through endosomes and the MAPK signaling pathway through recruitment of some of its components to late endosomes. May be involved in cholesterol homeostasis regulating LDL uptake and cholesterol release from late endosomes/lysosomes. May also play a role in RHOA activation.

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Keywords

LAMTOR1 Protein, Human, Recombinant (His) LAMTOR1 Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1 Protein associated with DRMs and endosomes Ragulator complex protein LAMTOR1 p27Kip1-releasing factor from RhoA Lipid raft adaptor protein p18 recombinant recombinant-proteins proteins protein

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

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