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Di-O-methylhonokiol

Name: Di-O-methylhonokiol
Brand: TargetMol
SKU: TN7231
Price: 795 CNY
Availability: InStock
Rating: 5 (10 reviews)

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很棒

纯度: 99.84%

货号 TN7231Cas号 68592-18-7

别名 和厚朴酚二甲醚, Honokiol dimethyl ether

Di-O-methylhonokiol (Honokiol dimethyl ether) 是Magnolia grandiflora L 的酚类成分，具有抗微生物活性，对革兰氏阳性和抗酸细菌和真菌具有显著的抗氧化活性。

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Di-O-methylhonokiol

一键复制产品信息

很棒

纯度: 99.84%

货号 TN7231 别名 和厚朴酚二甲醚, Honokiol dimethyl etherCas号 68592-18-7

Di-O-methylhonokiol (Honokiol dimethyl ether) 是Magnolia grandiflora L 的酚类成分，具有抗微生物活性，对革兰氏阳性和抗酸细菌和真菌具有显著的抗氧化活性。

规格	价格	库存
1 mg	¥ 795	现货
5 mg	¥ 1,990	现货
10 mg	¥ 3,150	现货
25 mg	¥ 4,970	现货
50 mg	¥ 6,990	现货
1 mL x 10 mM (in DMSO)	¥ 1,790	现货

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

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纯度: 99.84%

颜色: 白色

性状: Solid

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COA LCMS HNMR 产品操作手册

产品介绍

Di-O-methylhonokiol AI Summary

Di-O-methylhonokiol shows diverse bioactivities and potential therapeutic effects. It promotes neurite growth in rat cortical neurons, with notable activity at concentrations of 0.1 µM and 1 µM, and enhances neurite length by about 111 µM. The compound exhibits inhibitory effects on inflammatory enzymes, including 45% inhibition of COX1 in ram seminal vesicle and 47.8% inhibition of COX2 in sheep placental vesicle at an 8 µM concentration, with IC50 values of 11400.0 nM and 7700.0 nM, respectively. It also inhibits 5LOX-mediated LTB4 formation in stimulated human polymorphonuclear leukocytes, with a 27.8% inhibition and an IC50 value of 15000.0 nM. In addition, Di-O-methylhonokiol modulates the GABAAalpha1beta2 receptor by potentiating GABA-induced chloride current, exhibiting an EC50 of 42100.0 nM and maximal potentiation of 368% at 30 µM concentration. The compound has a high octanol-water partition coefficient (log P) of around 5.69, indicating higher hydrophobicity and potential for good membrane permeability. It shows antiproliferative activity against various human and mouse cell lines, including HUVEC, HepG2, LL/2, MCF7, CNE2Z, and I10 cells, with IC50 values indicating limited potency, generally above 100,000.0 nM. Di-O-methylhonokiol also demonstrates significant inhibition of LPS-induced COX2-mediated PGF1 production and NO production in mouse RAW264.7 cells, displaying cytotoxicity at higher concentrations. Furthermore, it acts as a CB2 receptor ligand with a Ki value of 1375.0 nM, showcasing its moderate affinity for this receptor. Overall, Di-O-methylhonokiol demonstrates a broad spectrum of bioactivities, including inflammation modulation, receptor activity modulation, and limited antiproliferative effects, with moderate hydrophobicity and potential membrane permeability..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述	Di-O-methylhonokiol (Honokiol dimethyl ether), a phenolic component of Magnolia grandiflora L, exhibits antimicrobial activity and significant antioxidant activity against Gram-positive and acid-resistant bacteria and fungi.
别名	和厚朴酚二甲醚, Honokiol dimethyl ether

化学信息

分子量	294.39
分子式	C₂₀H₂₂O₂
CAS No.	68592-18-7
Smiles	O(C)C1=C(C=C(CC=C)C=C1)C2=CC(CC=C)=C(OC)C=C2
密度	no data available

储存&溶解度

存储

溶解度信息

DMSO: 2.95 mg/mL (10.02 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3969 mL	16.9843 mL	33.9685 mL	169.8427 mL
5 mM	0.6794 mL	3.3969 mL	6.7937 mL	33.9685 mL
10 mM	0.3397 mL	1.6984 mL	3.3969 mL	16.9843 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。