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KAT5 Protein, Human, Recombinant (His)

KAT5 Protein, Human, Recombinant (His)

产品编号 TMPH-01470
别名: Protein 2-hydroxyisobutyryltransferase KAT5, Lysine acetyltransferase 5, Histone acetyltransferase KAT5, Histone acetyltransferase HTATIP, Protein crotonyltransferase KAT5, KAT5, Protein acetyltransferase KAT5, cPLA(2)-interacting protein, 60 kDa Tat-interactive protein

KAT5 Protein, Human, Recombinant (His) is expressed in E. coli.

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KAT5 Protein, Human, Recombinant (His)
规格 价格/CNY 货期 数量
20 μg ¥ 1,320 20日内发货
100 μg ¥ 2,470 20日内发货
1 mg ¥ 10,700 20日内发货
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产品目录号及名称: KAT5 Protein, Human, Recombinant (His) (TMPH-01470)
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生物活性
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产品性质
产品描述 KAT5 Protein, Human, Recombinant (His) is expressed in E. coli.
种属 Human
表达系统 E. coli
标签 N-6xHis
蛋白编号 Q92993
别名 Protein 2-hydroxyisobutyryltransferase KAT5, Lysine acetyltransferase 5, Histone acetyltransferase KAT5, Histone acetyltransferase HTATIP, Protein crotonyltransferase KAT5, KAT5, Protein acetyltransferase KAT5, cPLA(2)-interacting protein, 60 kDa Tat-interactive protein
氨基酸序列 EVGEIIEGCRLPVLRRNQDNEDEWPLAEILSVKDISGRKLFYVHYIDFNKRLDEWVTHERLDLKKIQFPKKEAKTPTKNGLPGSRPGSPEREVPASAQASGKTLPIPVQITLRFNLPKEREAIPGGEPDQPLSSSSCLQPNHRSTKRKVEVVSPATPVPSETAPASVFPQNGAARRAVAAQPGRKRKSNCLGTDEDSQDSSDGIPSAPRMTGSLVSDRSHDDIVTRMKNIECIELGRHRLKPWYFSPYPQELTTLPVLYLCEFCLKYGRSLKCLQRHLTKCDLRHPPGNEIYRKGTISFFEIDGRKNKSYSQNLCLLAKCFLDHKTLYYDTDPFLFYVMTEYDCKGFHIVGYFSKEKESTEDYNVACILTLPPYQRRGYGKLLIEFSYELSKVEGKTGTPEKPLSDLGLLSYRSYWSQTILEILMGLKSESGERPQITINEISEITSIKKEDVISTLQYLNLINYYKGQYILTLSEDIVDGHERAMLKRLLRIDSKCLHFTPKDWSKRGKW
蛋白构建 3-513 aa
蛋白纯度 > 90% as determined by SDS-PAGE.
分子量 62.4 kDa (predicted)
缓冲液 Tris-based buffer, 50% glycerol
复溶方法 A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储

Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

运输方式

In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.

研究背景 Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome. Also acetylates non-histone proteins, such as ATM, NR1D2, RAN, FOXP3, ULK1 and RUBCNL/Pacer. Directly acetylates and activates ATM. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity. Acetylates RAN at 'Lys-134'. Together with GSK3 (GSK3A or GSK3B), acts as a regulator of autophagy: phosphorylated at Ser-86 by GSK3 under starvation conditions, leading to activate acetyltransferase activity and promote acetylation of key autophagy regulators, such as ULK1 and RUBCNL/Pacer.

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Keywords

KAT5 Protein, Human, Recombinant (His) Protein 2-hydroxyisobutyryltransferase KAT5 Lysine acetyltransferase 5 Histone acetyltransferase KAT5 Histone acetyltransferase HTATIP Protein crotonyltransferase KAT5 KAT5 Protein acetyltransferase KAT5 cPLA(2)-interacting protein 60 kDa Tat-interactive protein recombinant recombinant-proteins proteins protein

 

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