360A iodide

产品编号 T13504Cas号 737763-37-0

别名 360 A iodide

360A iodide is a selective stabilizer of G-quadruplex and inhibits telomerase activity (IC50: 300 nM in TRAP-G4 assay).

产品编号 T13504别名 360 A iodideCas号 737763-37-0

360A iodide is a selective stabilizer of G-quadruplex and inhibits telomerase activity (IC50: 300 nM in TRAP-G4 assay).

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生物活性

产品描述	360A iodide is a selective stabilizer of G-quadruplex and inhibits telomerase activity (IC50: 300 nM in TRAP-G4 assay).
靶点活性	Telomerase:300 nM
体外活性	360A reduces the viability of glioma cell lines, such as CB193, T98G, U118-MG, SAOS-2, and Primary astrocytes, with IC50s of 3.9 μM, 4.8 μM, 8.4 μM, >15 μM and 17.4 μM, respectively [1]. 360A causes Rad51-dependent telomere aberrations preferentially involving the lagging strand telomeres, including telomere losses or telomere doublets, and induces DNA-PKcs-dependent sister telomere fusions [2].
细胞实验	In brief, cells are seeded at various densities, depending on cell type (0.25-4 × 10^3 cells/well in 100?μL complete medium), in 96-well culture plates and treated with various concentrations (0.1-20?μM) of 360A or the corresponding concentrations of DMSO (control wells) for 3 or 7 days at 37°C in an atmosphere containing 5% CO2. For 7-day assays, the medium is changed on day 3. Experiments are performed in triplicate [1].
别名	360 A iodide