TRPC3/6-IN-1

Name: TRPC3/6-IN-1
Brand: TargetMol
SKU: T61407
Rating: 4.5 (1 reviews)

还可以

产品编号 T61407Cas号 736945-96-3

TRPC3/6-IN-1 is a highly potent and selective inhibitor that specifically blocks the activity of the canonical transient receptor channels TRPC3 and TRPC6. It exhibits a significant blocking potency against the human isoforms hTRPC3 and hTRPC6, with IC50 values of 1260 nM and 500 nM, respectively. This compound, TRPC3/6-IN-1, is particularly valuable for conducting research on chronic models of heart failure [1].

TRPC3/6-IN-1

还可以

产品编号 T61407Cas号 736945-96-3

规格	价格	库存
1 mg	¥ 577	35日内发货
5 mg	¥ 1,870	35日内发货
10 mg	¥ 3,150	35日内发货
25 mg	¥ 6,420	35日内发货

大包装 & 定制

加入购物车

TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

联系我们获取更多批次信息

资源下载

产品操作手册

产品介绍

生物活性

产品描述	TRPC3/6-IN-1 is a highly potent and selective inhibitor that specifically blocks the activity of the canonical transient receptor channels TRPC3 and TRPC6. It exhibits a significant blocking potency against the human isoforms hTRPC3 and hTRPC6, with IC50 values of 1260 nM and 500 nM, respectively. This compound, TRPC3/6-IN-1, is particularly valuable for conducting research on chronic models of heart failure [1].
体外活性	TRPC3/6-IN-1 has block potency for hTRPC3 and hTRPC6 with IC 50 values of 1260 nM and 500 nM, respectively [1].
体内活性	TRPC3/6-IN-1 (compound 3) has good pharmacokinetic in rats [1]. Pharmacokinetic Parameters of TRPC3/6-IN-1 in rats [1]. Compd Dose(iv)(mg/kg) C max (iv)(ng/ml) CL(iv)(ml/min/kg) MRT(iv)(h) DNAUC(iv)(h kg/L) %F 3 0.93 250 120 0.3 0.14 ~1