hCAI/II-IN-2

Name: hCAI/II-IN-2
Brand: TargetMol
SKU: T61282
Rating: 4.5 (1 reviews)

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产品编号 T61282Cas号 2480283-75-6

hCAI/II-IN-2 (compound 2b) is a highly effective dual inhibitor of human carbonic anhydrase I and II (hCA I/II), with Ki values of 40.97 nM, 15.15 nM, and 61.88 nM for hCA I, hCA II, and hCA IX, respectively. With its anti-hypoxic properties, hCAI/II-IN-2 demonstrates activity against acute mountain sickness (AMS). Furthermore, this compound exhibits low cellular activity [1].

hCAI/II-IN-2

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产品编号 T61282Cas号 2480283-75-6

规格	价格	库存
25 mg	¥ 10,600	6-8周
50 mg	¥ 13,800	6-8周
100 mg	¥ 17,500	6-8周

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产品描述	hCAI/II-IN-2 (compound 2b) is a highly effective dual inhibitor of human carbonic anhydrase I and II (hCA I/II), with Ki values of 40.97 nM, 15.15 nM, and 61.88 nM for hCA I, hCA II, and hCA IX, respectively. With its anti-hypoxic properties, hCAI/II-IN-2 demonstrates activity against acute mountain sickness (AMS). Furthermore, this compound exhibits low cellular activity [1].
体外活性	hCAI/II-IN-2 (compound 2b) (5-200 μM, 48 hours; HEK293T cells) has no obvious toxicity at HEK293T cells [1]. Cell Cytotoxicity Assay [1] Cell Line: Embryonic kidney (HEK293T) cells Concentration: 5, 25, 50, 100 and 200 μM Incubation Time: 48 hours Result: Had no apparent cytotoxicity.
体内活性	Animal Model: Male BLAB/c mice [1] Dosage: 400 mg/kg Administration: Oral administration; 14 days. Result: Prolonged the survival time of mice by 21.7% compared with the blank control group.