M8891

Name: M8891
Brand: TargetMol
SKU: T11930
Rating: 4.5 (1 reviews)

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产品编号 T11930Cas号 1464842-09-8

M8891 is an orally active, reversible and brain penetrant Methionine Aminopeptidase-2 (MetAP-2) inhibitor(IC50 :54nM;Ki:4.33 nM).M8891 inhibits growth of primary endothelial cells as well as tumor cells and demonstrates antiangiogenic and antitumoral activity.

M8891

还可以

产品编号 T11930Cas号 1464842-09-8

规格	价格	库存
5 mg	¥ 4,820	6-8周
25 mg	¥ 10,600	6-8周
50 mg	¥ 13,800	6-8周
100 mg	¥ 17,500	6-8周

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产品描述	M8891 is an orally active, reversible and brain penetrant Methionine Aminopeptidase-2 (MetAP-2) inhibitor(IC50 :54nM;Ki:4.33 nM).M8891 inhibits growth of primary endothelial cells as well as tumor cells and demonstrates antiangiogenic and antitumoral activity.
靶点活性	MetAP2:(ki)4.33 nM , MetAP2:54 nM
体外活性	M8891 has an IC50 of 20 nM for HUVEC proliferation[1].
体内活性	M8891 (iv;?0.2 mg/kg) shows low clearance (CL ~0.03-0.4 L/h/kg corresponding to ~1-6% of the liver blood-flow), small to medium volume of distribution (Vss ~0.23-1.3 L/kg), and medium to high oral bioavailability (F ~40-80%)[1].?M8891 (po; 20 mg/kg; once a day for 14 days) exhibits strong tumor growth inhibition[1].