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Dimethyl fumarate (DMF) 是一种 Nrf2 激活剂,具有口服活性和血脑屏障渗透性。Dimethyl fumarate 具有抗菌、抗炎和免疫调节活性,被用于研究多发性硬化症。
Dimethyl fumarate (DMF) 是一种 Nrf2 激活剂,具有口服活性和血脑屏障渗透性。Dimethyl fumarate 具有抗菌、抗炎和免疫调节活性,被用于研究多发性硬化症。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
500 mg | ¥ 333 | 现货 | |
5 g | ¥ 460 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 460 | 现货 |
产品描述 | Dimethyl fumarate (DMF) is an Nrf2 activator with oral activity and blood-brain barrier permeability. Dimethyl fumarate has antimicrobial, anti-inflammatory, and immunomodulatory activities and has been used in the study of multiple sclerosis. |
体外活性 | 方法: 原代皮层培养物或海马 HT22 细胞用 Dimethyl fumarate (10 µM) 和 glutamate 处理 24 h,使用 Cell Titer Blue (CTB) assay 检测细胞活力。 结果: 与 10 µM MMF Dimethyl fumarate 预孵育 24 h 保护原代皮层培养物和海马 HT22 细胞免受氧化谷氨酸毒性。[1] 方法: 肿瘤细胞 CT26 用 Dimethyl fumarate (100 µM) 处理 3-24 h,使用 LDH cytotoxicity assay kit 检测 LDH 释放。 结果: Dimethyl fumarate 时间依赖性地增加 LDH 的释放,这反映了坏死细胞的死亡。[2] |
体内活性 | 方法: 为研究对弗里德里希共济失调 (FA) 的作用,将 Dimethyl fumarate (110 mg/kg) 口服给药给 FA 的 FXNKD 小鼠模型,每天一次,持续 18 周。 结果: Dimethyl fumarate 挽救了 FXNKD 小鼠模型的大脑中的这些酶活性,并挽救了脑、小脑和股四头肌中的 frataxin 和细胞色素氧化酶的表达。[3] |
别名 | 富马酸二甲酯, DMF |
分子量 | 144.13 |
分子式 | C6H8O4 |
CAS No. | 624-49-7 |
Smiles | COC(=O)\C=C\C(=O)OC |
密度 | 1.37 g/cm3 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
溶解度信息 | DMSO: 15 mg/mL (104.07 mM), Sonication is recommended. ![]() 10% DMSO+90% Saline: 1.5 mg/mL (10.41 mM), In vivo: Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. ![]() Ethanol: 7.2 mg/mL (50 mM) 5% DMSO+95% Saline: 0.29 mg/mL (2.01 mM), In vivo: Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. ![]() | |||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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