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HDAC8 Protein, Human, Recombinant (GST)

产品编号 TMPY-01333

别名: histone deacetylase 8, CDA07, MRXS6, RPD3, CDLS5, WTS, HD8, HDACL1

HDAC8 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 68 kDa and the accession number is Q9BY41-1.

TargetMol的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

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HDAC8 Protein, Human, Recombinant (GST)

规格	价格/CNY		货期	数量
100 μg	￥ 3,820		现货

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生物活性	Testing in progress
产品描述	HDAC8 Protein, Human, Recombinant (GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 68 kDa and the accession number is Q9BY41-1.

种属	Human
表达系统	Baculovirus Insect Cells
标签	C-GST
蛋白编号	Q9BY41-1
别名	histone deacetylase 8, CDA07, MRXS6, RPD3, CDLS5, WTS, HD8, HDACL1
蛋白构建	The full length of Human HDAC8 isoform 1 (NP_060956.1) (Met 1-Val 377) was expressed, fused with the GST tag at the C-terminus.
蛋白纯度	> 88 % as determined by SDS-PAGE
分子量	68 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing 50 mM Tris, 100 mM NaCl, 0.5 mM PMSF, 10% glycerol, pH 8.0.Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Histone deacetylase 8, also known as HDAC8 and HDACL1, is a nucleus and cytoplasm protein that belongs to the histone deacetylase family and HD type 1 subfamily. Histone deacetylases (HDACs) are a growing family of enzymes implicated in transcriptional regulation by affecting the acetylation state of core histones in the nucleus of cells. HDAC8 / HDACL1 is weakly expressed in most tissues. It is expressed at a higher level in the heart, brain, kidney, and pancreas and also in the liver, lung, placenta, prostate, and kidney. HDAC8 / HDACL1 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones ( H2A, H2B, H3, and H4 ). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC8 / HDACL1 may play a role in smooth muscle cell contractility. HDAC8 / HDACL1 may be a potential drug target for neuroblastoma differentiation therapy using selective inhibitors, avoiding unspecific side effects.

参考文献

1. Buggy JJ. et al.,2000, Biochem J. 350 (1): 199-205. 2. Krennhrubec K. et al., 2007, Bioorg Med Chem Lett. 17 (10): 2874-8. 3. Oehme I. et al., 2009, Expert Opin Investig Drugs.18 (11): 1605-17.

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Keywords

HDAC8 Protein, Human, Recombinant (GST) histone deacetylase 8 RPD-3 HD 8 MRXS-6 CDLS-5 CDA 07 CDA07 MRXS6 CDLS 5 HD-8 RPD3 CDLS5 WTS HDACL-1 MRXS 6 HD8 CDA-07 HDACL 1 HDACL1 RPD 3 recombinant recombinant-proteins proteins protein

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

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