J22352

Name: J22352
Brand: TargetMol
SKU: T11701
Price: 255 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T11701Cas号 2252395-44-9

J22352, a PROTAC (proteolysis-targeting chimeras)-like and highly selective HDAC6 inhibitor with an IC50 value of 4.7 nM, enhances anticancer effects in glioblastoma by promoting HDAC6 degradation. It does so by inhibiting autophagy and stimulating the antitumor immune response, further restoring host antitumor activity through the reduction of PD-L1's immunosuppressive activity.

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J22352

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产品编号 T11701Cas号 2252395-44-9

规格	价格	库存
2 mg	¥ 591	5日内发货
5 mg	¥ 997	6-8周
10 mg	¥ 1,720	6-8周
100 mg	¥ 7,820	6-8周
1 mL x 10 mM (in DMSO)	¥ 1,090	6-8周

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产品介绍

生物活性

产品描述	J22352, a PROTAC (proteolysis-targeting chimeras)-like and highly selective HDAC6 inhibitor with an IC50 value of 4.7 nM, enhances anticancer effects in glioblastoma by promoting HDAC6 degradation. It does so by inhibiting autophagy and stimulating the antitumor immune response, further restoring host antitumor activity through the reduction of PD-L1's immunosuppressive activity.
靶点活性	HDAC6:4.7 nM
体外活性	J22352 (10 μM; 24 hours) shows a dose-dependent decrease in HDAC6 protein abundance. J22352 (0.1-20 μM; 72 hours) decreases U87MG cell viability in a dose-dependent manner.
体内活性	J22352 is well tolerated in mice.J22352 (10?mg/kg; given i.p. per day for 14 days in male nude mice) results in a >80% tumor growth inhibition (TGI) rate.

化学信息

分子量	415.44
分子式	C₂₄H₂₁N₃O₄
CAS No.	2252395-44-9
密度	1.343 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 125 mg/mL (300.89 mM), Sonication is recommended.

溶液配制表

	1mg	5mg	10mg	50mg
1 mM	2.4071 mL	12.0354 mL	24.0709 mL	120.3543 mL
5 mM	0.4814 mL	2.4071 mL	4.8142 mL	24.0709 mL
10 mM	0.2407 mL	1.2035 mL	2.4071 mL	12.0354 mL
20 mM	0.1204 mL	0.6018 mL	1.2035 mL	6.0177 mL
50 mM	0.0481 mL	0.2407 mL	0.4814 mL	2.4071 mL
100 mM	0.0241 mL	0.1204 mL	0.2407 mL	1.2035 mL