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The KD values of D13-9001 in Escherichia coli and Pseudomonas aeruginosa were 1.15μM and 3.57μM, respectively. D13-9001 has antibiotic activity. It is an effective AcrB (AcrAB-TolC efflux pump subunit) and MexB (MexAB-OprM efflux pump subunit) inhibitor.
The KD values of D13-9001 in Escherichia coli and Pseudomonas aeruginosa were 1.15μM and 3.57μM, respectively. D13-9001 has antibiotic activity. It is an effective AcrB (AcrAB-TolC efflux pump subunit) and MexB (MexAB-OprM efflux pump subunit) inhibitor.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5 mg | ¥ 9,800 | 期货 |
产品描述 | The KD values of D13-9001 in Escherichia coli and Pseudomonas aeruginosa were 1.15μM and 3.57μM, respectively. D13-9001 has antibiotic activity. It is an effective AcrB (AcrAB-TolC efflux pump subunit) and MexB (MexAB-OprM efflux pump subunit) inhibitor. |
靶点活性 | MexB:3.57 μM (kd), AcrB:(kd)1.15 μM |
体外活性 | D13-9001 has high solubility and good safety. |
体内活性 | Compared with AZT treated alone, D13-9001 (1.25-20 mg / kg; intravenous infusion; 2 hours) using aztreonam (AZT) can improve the survival rate of lethal pneumonia rats at the end of the seventh day . |
分子量 | 693.78 |
分子式 | C31H39N11O6S |
CAS No. | 957471-96-4 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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