Nonsteroidal aromatase inhibitor 1 (Compound 13h) effectively inhibits the enzyme CYP19A1 with an IC50 value of 0.09 nM. Due to its potent inhibitory activity, Nonsteroidal aromatase inhibitor 1 holds promise for research in the field of breast cancer [1].

Nonsteroidal aromatase inhibitor 1 (0.001 pM-100 pM; 1 h) treatment shows excellent aromatase inhibition activity [1]. Nonsteroidal aromatase inhibitor 1 (1 μM; 48 h) treatment has no impact on MCF-10A or MDA-MB-231 growth [1]. Cell Viability Assay [1] Cell Line: JEG-3 cells Concentration: 0.001 pM-100 pM Incubation Time: 1 hour Result: Showed excellent aromatase inhibition with the IC 50 value of 0.09 nM. Cell Cytotoxicity Assay [1] Cell Line: MCF-10A and MDA-MB-231 cells Concentration: 1 μM Incubation Time: 48 hour Result: Suggested possible limited toxicity in normal breast tissue and little off-target effects.