PMVK is a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Studies in rat show that the message level and the enzyme activity of PMVK is regulated by sterol, and that this regulation is coordinated with 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol biosynthesis.
生物活性 | Kinase activity untested |
产品描述 | PMVK is a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Studies in rat show that the message level and the enzyme activity of PMVK is regulated by sterol, and that this regulation is coordinated with 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol biosynthesis. |
种属 | Human |
表达系统 | E. coli |
标签 | N-His |
蛋白编号 | Q15126 |
别名 | PMK, PMKA, phosphomevalonate kinase, HUMPMKI, PMKASE |
蛋白构建 | mature form of Human PMVK(Q15126) (Met1-Leu192) |
蛋白纯度 | > 90 % as determined by SDS-PAGE |
分子量 | 23.8 kDa (predicted) |
内毒素 | Please contact us for more information. |
缓冲液 | Supplied as sterile 50 mM MOPS, 150 mM KCl, 1 mM DTT, pH 7.0. |
复溶方法 | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
存储 |
It is recommended to store the product under sterile conditions at -20°C to -80°C. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
运输方式 |
Kinases are highly recommended to be shipped at frozen temperature with blue ice or dry ice. |
研究背景 | PMVK is a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Studies in rat show that the message level and the enzyme activity of PMVK is regulated by sterol, and that this regulation is coordinated with 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol biosynthesis. |
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PMVK Protein, Human, Recombinant (His) PMK PMKA phosphomevalonate kinase HUMPMKI PMKASE recombinant recombinant-proteins proteins protein