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Propafenone (Propafenonum) 是钠通道阻滞剂,它对 β 受体具有高亲和力 (IC50=32 nM)。它能够阻断瞬时外向钾电流 (Ito) (IC50: 4.9 nM) 和持续延迟整流器K+电流 (Isus) (IC50: 8.6 nM) ,具有抗心律失常的作用。它能够诱导线粒体功能障碍及诱导细胞凋亡,从而抑制食管癌增殖。
Propafenone (Propafenonum) 是钠通道阻滞剂,它对 β 受体具有高亲和力 (IC50=32 nM)。它能够阻断瞬时外向钾电流 (Ito) (IC50: 4.9 nM) 和持续延迟整流器K+电流 (Isus) (IC50: 8.6 nM) ,具有抗心律失常的作用。它能够诱导线粒体功能障碍及诱导细胞凋亡,从而抑制食管癌增殖。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5 mg | ¥ 185 | 现货 | |
10 mg | ¥ 258 | 现货 | |
25 mg | ¥ 413 | 现货 | |
50 mg | ¥ 662 | 现货 | |
100 mg | ¥ 1,070 | 现货 | |
200 mg | ¥ 1,580 | 现货 | |
500 mg | ¥ 2,680 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 227 | 现货 |
产品描述 | Propafenone (Propafenonum) is only found in individuals that have used or taken this drug. It is an antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated. The electrophysiological effect of propafenone manifests itself in a reduction of upstroke velocity (Phase 0) of the monophasic action potential. In Purkinje fibers, and to a lesser extent myocardial fibers, propafenone reduces the fast inward current carried by sodium ions, which is responsible for the drugs antiarrhythmic actions. Diastolic excitability threshold is increased and effective refractory period prolonged. Propafenone reduces spontaneous automaticity and depresses triggered activity. At very high concentrations in vitro, propafenone can inhibit the slow inward current carried by calcium but this calcium antagonist effect probably does not contribute to antiarrhythmic efficacy. |
别名 | 普罗帕酮, Rythmol, Propafenonum |
分子量 | 341.44 |
分子式 | C21H27NO3 |
CAS No. | 54063-53-5 |
Smiles | O(CC(CNCCC)O)C1=C(C(CCC2=CC=CC=C2)=O)C=CC=C1 |
密度 | 1.096 g/cm3 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 25 mg/mL (73.22 mM) | ||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||
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