AG-10

Name: AG-10
Brand: TargetMol
SKU: T9447
Price: 1080 USD
Availability: InStock
Rating: 5 (10 reviews)

很棒

产品编号 T9447Cas号 1446711-81-4

别名 Acoramidis

AG-10 (Acoramidis) 是选择性的、口服有效的甲状腺素转运蛋白 (TTR (transthyretin)) 的稳定剂，显示出对野生型和 V1221 突变型均有效。

很棒

纯度: 99.77%

产品编号 T9447 别名 AcoramidisCas号 1446711-81-4

AG-10 (Acoramidis) 是选择性的、口服有效的甲状腺素转运蛋白 (TTR (transthyretin)) 的稳定剂，显示出对野生型和 V1221 突变型均有效。

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纯度:99.77%

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生物活性

产品描述	AG-10 (Acoramidis) is an orally active and selective kinetic stabilizer of TTR (transthyretin). AG-10 exhibits activity for WT and V122I-TTR. AG-10 is used in the study of transthyretin amyloidosis.
体外活性	AG-10 (0.1-10 μM for TTR ∼5 µM) stabilizes WT- and V122I-TTR equally well and also exceeds their efficacy to stabilize WT and mutant TTR in whole serum. AG-10 exhibits minimal inhibition of two common off-targets in drug discovery, the potassium ion channel hERG (IC50 > 100 µM) and a number of cytochrome P450 isozymes (IC50 > 50 µM) (low toxicity)[1]. AG-10 (10-100 μM) stimulates the mitochondrial QO2 in a concentration-dependent manner[2].
体内活性	AG-10 (Oral gavage; 50 mg/kg/d; daily for 28 d) exhibited the plasma Cmax of ∼40 µM and histopathological evaluation of liver, thymus, kidney, spleen, heart, and lung showed no signs of pathologic processes in the AG10-treated Wistar rats[1].
别名	Acoramidis