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Acotiamide monohydrochloride trihydrate (Z-338 HCl) 是一种首创的、具有口服活性的胃肠动力药。它通过促毒蕈碱受体拮抗作用和乙酰胆碱酯酶(AChE)抑制作用增强肠神经元释放的乙酰胆碱,从而增强胃排空和胃部适应性,有潜力用于功能性消化不良的研究。
Acotiamide monohydrochloride trihydrate (Z-338 HCl) 是一种首创的、具有口服活性的胃肠动力药。它通过促毒蕈碱受体拮抗作用和乙酰胆碱酯酶(AChE)抑制作用增强肠神经元释放的乙酰胆碱,从而增强胃排空和胃部适应性,有潜力用于功能性消化不良的研究。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5 mg | ¥ 129 | 现货 | |
10 mg | ¥ 222 | 现货 | |
25 mg | ¥ 395 | 现货 | |
50 mg | ¥ 587 | 现货 | |
100 mg | ¥ 882 | 现货 | |
200 mg | ¥ 1,370 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 156 | 现货 |
产品描述 | Acotiamide monohydrochloride trihydrate (Z-338 HCl) is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. Although the exact mechanism by which acotiamide exerts its effect has yet to be fully elucidated, this agent appears to inhibit acetylcholinesterase (AchE), an enzyme responsible for the breakdown of acetylcholine (Ach). Increased Ach concentrations lead to an improvement of gastric emptying and GI motility and eventually to a reduction of dyspepsia symptoms. |
别名 | Acotiamide hydrochloride, YM-443 HCl, 盐酸阿考替胺, Z-338 HCl |
分子量 | 541.06 |
分子式 | C21H37ClN4O8S |
CAS No. | 773092-05-0 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 27.5 mg/mL (50.83 mM) | ||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||
DMSO
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