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c-Myc inhibitor15 (Compound A5) 是一种特异性c-Myc抑制剂,通过干扰c-Myc与Max的相互作用来抑制癌症发展,导致c-Myc蛋白降解并引发凋亡 (Apoptosis)。在 A549 和 NCI-H1299 肺癌细胞系中,其IC50分别为4.08 μM和7.86 μM,显示出显著的细胞毒性。在同种异体肿瘤模型中,c-Myc inhibitor15 具有优异的抗肿瘤活性,肿瘤生长抑制率达76.4%,并有效降低了c-Myc蛋白的表达水平。此化合物有望应用于与c-Myc相关的肺癌研究中。
c-Myc inhibitor15 (Compound A5) 是一种特异性c-Myc抑制剂,通过干扰c-Myc与Max的相互作用来抑制癌症发展,导致c-Myc蛋白降解并引发凋亡 (Apoptosis)。在 A549 和 NCI-H1299 肺癌细胞系中,其IC50分别为4.08 μM和7.86 μM,显示出显著的细胞毒性。在同种异体肿瘤模型中,c-Myc inhibitor15 具有优异的抗肿瘤活性,肿瘤生长抑制率达76.4%,并有效降低了c-Myc蛋白的表达水平。此化合物有望应用于与c-Myc相关的肺癌研究中。
规格 | 价格 | 库存 | 数量 |
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10 mg | 询价 | 期货 | |
50 mg | 询价 | 期货 |
产品描述 | c-Myc inhibitor15 (Compound A5) is a selective c-Myc inhibitor that disrupts the interaction between c-Myc and Max, leading to c-Myc protein degradation and apoptosis (Apoptosis). It exhibits potent cytotoxic activity with IC50 values of 4.08 μM and 7.86 μM in A549 and NCI–H1299 lung cancer cell lines, respectively. In an allogeneic tumor model, c-Myc inhibitor15 demonstrated outstanding antitumor efficacy, achieving a tumor growth inhibition rate of 76.4% and significantly reducing c-Myc protein expression. This compound shows promise for research related to c-Myc-associated lung cancer. |
分子量 | 457.57 |
分子式 | C27H31N5O2 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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