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LRP-6 Protein, Human, Recombinant (Avi & His), Biotinylated
产品编号 TMPY-07087
LRP-6 Protein, Human, Recombinant (Avi & His), Biotinylated is expressed in HEK293 Cells. The accession number is O75581.
LRP-6 Protein, Human, Recombinant (Avi & His), Biotinylated
产品编号 TMPY-07087
LRP-6 Protein, Human, Recombinant (Avi & His), Biotinylated is expressed in HEK293 Cells. The accession number is O75581.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 20 μg | ¥ 3,820 | 期货 | |
| 100 μg | ¥ 8,830 | 期货 |
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| 生物活性 | 1.Loaded LRP-6 Protein, Human, Recombinant (Avi & His), Biotinylated (Cat#TMPY-07087) on SA Biosensor, can bind DKK1 Protein, Human, Recombinant (His) (Cat#TMPY-00775) with an affinity constant of 90.6 nM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested). 2.Loaded LRP-6 Protein, Human, Recombinant (Avi & His), Biotinylated (Cat#TMPY-07087) on SA Biosensor, can bind RSPO1 Protein, Human, Recombinant (His) (Cat#TMPY-01147) with an affinity constant of 4.25 nM as determined in BLI assay (Sartorius Octet RED384) (QC tested). 3.Loaded LRP-6 Protein, Human, Recombinant (Avi & His), Biotinylated (Cat#TMPY-07087) on SA Biosensor, can bind SOST/Sclerostin Protein, Human, Recombinant (His) (Cat#TMPY-00925) with an affinity constant of 39.5 nM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested). 4.Loaded LRP-6 Protein, Human, Recombinant (Avi & His), Biotinylated (Cat#TMPY-07087) on SA Biosensor, can bind DKK1 Protein, Human, Recombinant (hFc) (Cat#TMPY-05479) with an affinity constant of 54.3 nM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested). |
| 产品描述 | LRP-6 Protein, Human, Recombinant (Avi & His), Biotinylated is expressed in HEK293 Cells. The accession number is O75581. |
| 种属 | Human |
| 表达系统 | HEK293 Cells |
| 标签 | C-His-Avi |
| 蛋白编号 | O75581 |
| 别名 | STHAG7,ADCAD2 |
| 蛋白构建 | A DNA sequence encoding the Human LRP6 (O75581) (Met1-Pro630) was expressed with a C-terminal polyhistidine tag followed by an AVI tag. The expressed protein was biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed. |
| 蛋白纯度 | ≥ 90% as determined by SDS-PAGE. |
| 分子量 | 72.22 kDa (predicted); 79.8 kDa (reducing contition) |
| 内毒素 | < 1.0 EU per μg protein as determined by the LAL method. |
| 缓冲液 | Lyophilized from sterile PBS, pH 7.4. Please contact us for any concerns or special requirements. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA. |
| 复溶方法 | Please refer to the lot-specific COA. |
| 存储 | It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
| 运输方式 | In general, Lyophilized powders are shipping with blue ice. |
| 研究背景 | Lipoprotein receptor-related protein 6 (LRP6) binds to Wnt ligands to transduce signal by stabilization of beta-catenin, which has been involved in the regulation of embryonic development and metabolism. Low density lipoprotein (LDL) receptor-related protein-6 (LRP6) is an important co-receptor of Wnt pathway, which plays a predominant role in the development and progression of colorectal cancer. This gene, termed LDL receptor-related protein 6 (LRP6), encodes a transmembrane protein that has 71% identity and is structurally similar to the protein encoded by LRP5, a proposed candidate gene for type 1 diabetes located on human chromosome 11q13. LRP6 maps to human chromosome 12p11-p13. |
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