ITK Protein, Human, Recombinant (Actived By LCK, GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 57.7 kDa and the accession number is Q08881.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
50 μg | ¥ 3,170 | 5日内发货 |
生物活性 | Testing in progress |
产品描述 | ITK Protein, Human, Recombinant (Actived By LCK, GST) is expressed in Baculovirus insect cells with GST tag. The predicted molecular weight is 57.7 kDa and the accession number is Q08881. |
种属 | Human |
表达系统 | Baculovirus Insect Cells |
标签 | N-GST |
蛋白编号 | Q08881 |
别名 | LYK, PSCTK2, LPFS1, IL2-inducible T-cell kinase, EMT |
蛋白构建 | The Human ITK (NP_005537.3) (Arg352-Leu620) was expressed with a GST tag at the N-terminus. The purified ITK was actived by LCK. |
蛋白纯度 | > 75 % as determined by SDS-PAGE. |
分子量 | 57.7 kDa (predicted) |
内毒素 | < 1.0 EU/μg of the protein as determined by the LAL method. |
缓冲液 | Supplied as sterile 50 mM Tris, 150 mM NaCl, pH 7.5, 25% glycerol, 0.5 mM PMSF, 0.5 mM TCEP, 0.1 mM EDTA, 0.5 mM GSH. |
复溶方法 | A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information. |
存储 |
It is recommended to store the product under sterile conditions at -20°C to -80°C. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
运输方式 |
In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice. |
研究背景 | IL-2-inducible T cell kinase is a member of the protein kinase superfamily, Tyr protein kinase family, and TEC subfamily. It contains 1 Btk-type zinc finger, 1 PH domain, 1 protein kinase domain, 1 SH2 domain, and 1 SH3 domain. As an intracellular kinase expressed in T-cells, IL-2-inducible T cell kinase contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. It regulates the development, function, and differentiation of conventional T-cells and nonconventional NKT-cells. IL-2-inducible T cell kinase also plays an essential role in the regulation of the adaptive immune response. Effects in IL-2-inducible T cell kinase are the cause of lymphoproliferative syndrome EBV-associated autosomal type 1 (LPSA1). LPSA1 is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Inadequate immune response to EBV can have a fatal outcome. Clinical features include splenomegaly, lymphadenopathy, anemia, thrombocytopenia, pancytopenia, recurrent infections. There is an increased risk of lymphoma. |
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ITK Protein, Human, Recombinant (Actived By LCK, GST) PSCTK 2 LYK LPFS-1 PSCTK2 LPFS1 IL2-inducible T-cell kinase PSCTK-2 LPFS 1 EMT recombinant recombinant-proteins proteins protein