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CD55/DAF Protein, Mouse, Recombinant (hFc)

产品编号 TMPY-06679

别名: Daf, CD55 molecule, decay accelerating factor for complement (Cromer blood group), Daf-GPI, GPI-DAF, Daf1

CD55/DAF Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 62.48 kDa and the accession number is Q61475.

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CD55/DAF Protein, Mouse, Recombinant (hFc)

规格	价格/CNY		货期	数量
100 μg	￥ 3,820		5日内发货
1 mg	￥ 24,900		5日内发货

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生物活性	Testing in progress
产品描述	CD55/DAF Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 62.48 kDa and the accession number is Q61475.

种属	Mouse
表达系统	HEK293 Cells
标签	C-hFc
蛋白编号	Q61475
别名	Daf, CD55 molecule, decay accelerating factor for complement (Cromer blood group), Daf-GPI, GPI-DAF, Daf1
蛋白构建	The Mouse CD55 (Q61475) (Met1-Thr361) was expressed with the Fc region of Human IgG1 at the C-terminus.
蛋白纯度	≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.
分子量	62.48 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	CD55, also well known as decay-accelerating factor (DAF), is a member of the RCA (regulators of complement activation) family characterized by four to 30 SCRs (short consensus repeats) in their plasma-exposed regions. It is a major regulator of the alternative and classical pathways of complement activation and is expressed on all serum-exposed cells. CD55 is physiologically acting as an inhibitor of the complement system, but is also broadly expressed in malignant tumours. DAF seems to exert different functions beyond its immunological role such as promotion of tumorigenesis, decrease of complement mediated tumor cell lysis, autocrine loops for cell rescue and evasion of apoptosis, neoangiogenesis, invasiveness, cell motility. It is commonly hijacked by invading pathogens, including many enteroviruses and uropathogenic Escherichia coli, to promote cellular attachment prior to infection. This 70-75 kDa glycoprotein CD55 containing four SCR modules is involved in the regulation of the complement cascade. It inhibits complement activation by suppressing the function of C3/C5 convertases, thereby limiting local generation or deposition of C3a/C5a and membrane attack complex (MAC or C5b-9) production. DAF has been identified as a ligand for an activation-associated, seven-transmembrane lymphocyte receptor, CD97, which is a receptor mediating attachment and infection of several viruses and bacteria. In addition, it has been shown that DAF regulates the interplay between complement and T cell immunity in vivo, and thus may be implicated in immune and tumor biology.

参考文献

1. Lea S. (2002) Interactions of CD55 with non-complement ligands. Biochem Soc Trans. 30(Pt 6): 1014-9. 2. Mikesch JH,et al.(2006) The expression and action of decay-accelerating factor (CD55) in human malignancies and cancer therapy. Cell Oncol. 28(5-6): 223-32. 3. Wang Y,et al.(2010) Decay accelerating factor (CD55) protects neuronal cells from chemical hypoxia-induced injury. J Neuroinflammation. 7:24.

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Keywords

CD55/DAF Protein, Mouse, Recombinant (hFc) Daf CD55 molecule, decay accelerating factor for complement (Cromer blood group) Cromer blood group Daf-GPI GPI-DAF Daf1 recombinant recombinant-proteins proteins protein

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