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(±)5-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 5(S)-HEPE and 5(R)-HEPE. The biological activity of (±)5-HEPE is likely mediated by one of the individual isomers, most commonly the 5(S) isomer in mammalian systems. EPA can be metabolized to 5-HEPE in human and bovine neutrophils, and human eosinophils, which is further metabolized to 5-oxoEPE and LTB5. The 5-series metabolites of EPA, namely 5-HEPE, 5-oxoEPE, and LTB5, have significantly decreased biological effects compared to the arachidonic acid-derived metabolites.
(±)5-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 5(S)-HEPE and 5(R)-HEPE. The biological activity of (±)5-HEPE is likely mediated by one of the individual isomers, most commonly the 5(S) isomer in mammalian systems. EPA can be metabolized to 5-HEPE in human and bovine neutrophils, and human eosinophils, which is further metabolized to 5-oxoEPE and LTB5. The 5-series metabolites of EPA, namely 5-HEPE, 5-oxoEPE, and LTB5, have significantly decreased biological effects compared to the arachidonic acid-derived metabolites.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
25 μg | ¥ 1,980 | 35日内发货 | |
50 μg | ¥ 3,880 | 35日内发货 | |
100 μg | ¥ 7,330 | 35日内发货 | |
250 μg | ¥ 16,200 | 35日内发货 |
产品描述 | (±)5-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 5(S)-HEPE and 5(R)-HEPE. The biological activity of (±)5-HEPE is likely mediated by one of the individual isomers, most commonly the 5(S) isomer in mammalian systems. EPA can be metabolized to 5-HEPE in human and bovine neutrophils, and human eosinophils, which is further metabolized to 5-oxoEPE and LTB5. The 5-series metabolites of EPA, namely 5-HEPE, 5-oxoEPE, and LTB5, have significantly decreased biological effects compared to the arachidonic acid-derived metabolites. |
分子量 | 318.457 |
分子式 | C20H30O3 |
CAS No. | 83952-40-3 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
溶解度信息 | PBS (pH 7.2): 0.8 mg/mL (2.51 mM), Sonication is recommended. DMSO: Miscible 0.1 M Na2CO3: 2 mg/mL (6.28 mM), Sonication is recommended. Ethanol: Miscible DMF: Miscible | ||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||
PBS (pH 7.2)/0.1 M Na2CO3
0.1 M Na2CO3
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