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R-Spondin 2/RSPO2 Protein, Mouse, Recombinant (mFc)

产品编号 TMPY-00223

别名: D430027K22, ftls, AA673245, 2610028F08Rik, R-spondin 2

R-Spondin 2/RSPO2 Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 47.4 kDa and the accession number is Q8BFU0.

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R-Spondin 2/RSPO2 Protein, Mouse, Recombinant (mFc)

规格	价格/CNY		货期	数量
50 μg	￥ 2,440		5日内发货

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生物活性	Testing in progress
产品描述	R-Spondin 2/RSPO2 Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 47.4 kDa and the accession number is Q8BFU0.

种属	Mouse
表达系统	HEK293 Cells
标签	C-mFc
蛋白编号	Q8BFU0
别名	D430027K22, ftls, AA673245, 2610028F08Rik, R-spondin 2
蛋白构建	The Mouse Rspo2 (NP_766403.1) (Met1-Gly205) was expressed with the Fc region of Mouse IgG1 at the C-terminus.
蛋白纯度	> 85 % as determined by SDS-PAGE.
分子量	47.4 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	R-spondin-2, also known as RSPO2, synergizes with Wnt to activate beta-catenin. RSPO2 is secreted proteins that regulate beta-catenin signaling. Activator of the beta-catenin signaling cascade leads to TCF-dependent gene activation. Action both in the canonical Wnt / beta- catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled / LRP receptors. Probably also acts as a ligand for frizzled and LRP receptors. The encoding gene Rspo2 was identified as a novel common integration site for the mouse mammary tumor virus in viral induced mouse mammary tumors. Rspo2 and Rspo2 / Wnt1 tumors contained many spindle cells, consistent with an epithelial-mesenchymal transformation phenotype. When Rspo2 and Rspo2 / Wnt1 tumor cells were transferred into naive mice, they exhibited greater metastatic activity than cells derived from Wnt1 tumors.

参考文献

1. Cadieu E, et al. (2009) Coat Variation in the Domestic Dog Is Governed by Variants in Three Genes. Science. 326: 150-153. 2. Kazanskaya O, et al. (2004) R-Spondin2 is a secreted activator of Wnt / beta-catenin signaling and is required for Xenopus myogenesis. Dev Cell. 7(4): 525-34. 3. Parker HG, et al. (2010) An insertion in the RSPO2 gene correlates with improper coat in the Portuguese water dog. J Hered. 101(5):612-7.

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Keywords

R-Spondin 2/RSPO2 Protein, Mouse, Recombinant (mFc) D430027K22 AA-673245 ftls AA673245 2610028F08Rik R-spondin 2 AA 673245 recombinant recombinant-proteins proteins protein

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