Norswertianolin

Name: Norswertianolin
Brand: TargetMol
SKU: T40629
Price: 1490 USD
Availability: InStock
Rating: 5 (10 reviews)

很棒

产品编号 T40629Cas号 54954-12-0

Norswertianolin, a compound isolated from G. acuta, functions as a CSE activator and shows promise as a potential cardiovascular therapeutic.

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很棒

产品编号 T40629Cas号 54954-12-0

Norswertianolin, a compound isolated from G. acuta, functions as a CSE activator and shows promise as a potential cardiovascular therapeutic.

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产品介绍

生物活性

产品描述	Norswertianolin, a compound isolated from G. acuta, functions as a CSE activator and shows promise as a potential cardiovascular therapeutic.
体外活性	Norswertianolin (3.125~50 μM; H9c2 cells) has the protective effects on H 2 O 2 -induced H9c2 cells. Norswertianolin significantly increases the transcription levels of HO-1 and GCLC in H9c2 cells[1]. Norswertianolin (0~150 μM; HepG2 cells) high concentration increases the CSE protein level[2].
体内活性	Norswertianolin (4.4 mg/kg/day; s.c.; 1 week) improves CSE/H 2 S production[2]. Norswertianolin treatment attenuates the renal tubular injury in acute I/R. Norswertianolin also reduces I/R-stimulated ROS by DHE fluorescence intensity. Norswertianolin has anti-hypertension effects, inhibits vascular remodeling and reduces inflammation effects[2]. Animal Model: Male Sprague Dawley rats (10~12 weeks)[2]Dosage: 4.4 mg/kg/day Administration: S.c. Result: Improved CSE/H 2 S production.

化学信息

分子量	422.34
分子式	C₁₉H₁₈O₁₁
CAS No.	54954-12-0
Smiles	OC[C@H]1O[C@@H](Oc2ccc(O)c3oc4cc(O)cc(O)c4c(=O)c23)[C@H](O)[C@@H](O)[C@@H]1O

储存&溶解度

存储	keep away from direct sunlight,keep away from moisture,store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.