SIQ17, an EGFR inhibitor, blocks the ATP-binding site with an IC50 of 0.62 nM, demonstrating more effective EGFR-TK inhibitory activity than the known inhibitor Erlotinib (IC50 of ∼20 nM). SIQ17 is applicable in cancer research [1].

SIQ17 (10 μM, 72小时) 对 A431 细胞的活力抑制作用更强于 A549 细胞 [1]。SIQ17 (0-100 μM, 24小时) 对 A549 和 A431 细胞毒性作用，IC 50 s 分别为 32.98 μM 和 19.17 μM [1]。Cell Viability Assay [1] Cell Line: A549, A431 Concentration: 10 μM Incubation Time: 72 hours Result: Had a stronger inhibits on cell viability of A431 cells compare to A549 cells Cell Cytotoxicity Assay [1] Cell Line: A549, A431, Vero cell lines Concentration: 0-100 μM Incubation Time: 24 hours Result: Had thecytotoxic effects, with IC 50 s of 32.98 μM and 19.17 μM for A549 cells and A431 cells respectively.