购物车
- 全部删除
- 您的购物车当前为空
p53-MDM2-IN-6, LSM-83177腙类似物,展现出显著的p53-MDM2抑制效果,其IC50值为11.08 µg/mL。该化合物能够诱导S期细胞周期阻滞以及早期与晚期的细胞凋亡 (Apoptosis),在HT29细胞系表现出强烈的抗增殖性,IC50值为10.44 µg/mL。通过抑制p53-MDM2相互作用,p53-MDM2-IN-6可提升p-53水平并降低GST酶表达,显示其在结直肠癌研究中的潜力。
p53-MDM2-IN-6, LSM-83177腙类似物,展现出显著的p53-MDM2抑制效果,其IC50值为11.08 µg/mL。该化合物能够诱导S期细胞周期阻滞以及早期与晚期的细胞凋亡 (Apoptosis),在HT29细胞系表现出强烈的抗增殖性,IC50值为10.44 µg/mL。通过抑制p53-MDM2相互作用,p53-MDM2-IN-6可提升p-53水平并降低GST酶表达,显示其在结直肠癌研究中的潜力。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | p53-MDM2-IN-6, an LSM-83177 hydrazone analog, acts as an efficacious p53-MDM2 inhibitor with an IC50 of 11.08 µg/mL. This compound inhibits the p53-MDM2 interaction leading to an increase in p-53 levels while concurrently decreasing GST enzyme expression. It halts the cell cycle at the S phase and induces early and late apoptosis (Apoptosis), exhibiting antiproliferative activity against the HT29 cell line with an IC50 of 10.44 µg/mL. p53-MDM2-IN-6 holds promise for research in colorectal cancer. |
分子量 | 327.33 |
分子式 | C17H17N3O4 |
CAS No. | 1054506-59-0 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
评论内容