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REG1B Protein, Human, Recombinant (His)

产品编号 TMPY-01394

别名: regenerating islet-derived 1 beta, PSPS2, REGL, regenerating islet-derived 1 β, REGH, REGI-β, REGI-BETA

REG1B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.7 kDa and the accession number is P48304.

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REG1B Protein, Human, Recombinant (His)

规格	价格/CNY		货期	数量
100 μg	￥ 4,460		5日内发货

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参考文献

生物活性	Testing in progress
产品描述	REG1B Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.7 kDa and the accession number is P48304.

种属	Human
表达系统	HEK293 Cells
标签	C-His
蛋白编号	P48304
别名	regenerating islet-derived 1 beta, PSPS2, REGL, regenerating islet-derived 1 β, REGH, REGI-β, REGI-BETA
蛋白构建	The Human REG1B (NP_006498.1) (Met 1-Asn 166) was fused with a polyhistidine tag at the C-terminus.
蛋白纯度	> 95 % as determined by SDS-PAGE
分子量	17.7 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice.
研究背景	Regenerating gene (Reg), first isolated from a regenerating islet cDNA library, encodes a secretory protein with a growth stimulating effect on pancreatic beta cells, and could be associated with fibrocalculous pancreatopathy. Reg and Reg-related genes which were expressed in various organs have been revealed to constitute a multigene family, the Reg family consisting of four subtypes (types I, II, III, IV) and are involved in cancers and neurodegenerative diseases. Regenerating islet-derived 1 beta (REG1B), also known as Lithostathine-1-beta and Pancreatic stone protein 2 (PSPS2), is a types I Reg protein and contains one typical C-type lectin domain. REG1B is a 166-amino acid protein that has 22 amino acid substitutions in comparison with the previously isolated human REG1A, and it is was expressed only in pancreas. REG1B Is normally found in the exocrine pancreas, whereas in other tissues it appears either only under pathological conditions, such as Alzheimer's disease (brain), cancer (colon), or during regeneration such as neuronal sprouting in brain and pancreas regeneration. REG1B might act as an inhibitor of spontaneous calcium carbonate precipitation. The REG1A and REG1B gene and proteins could play different roles in the pancreas.

参考文献

1. Moriizumi S,et al.(1994) Isolation, structural determination and expression of a novel reg gene, human regI beta. Biochim Biophys Acta. 1217(2): 199-202. 2. Sanchez D,et al.(2001) Preferential expression of reg I beta gene in human adult pancreas. Biochem Biophys Res Commun. 284(3): 729-37. 3. Boonyasrisawat W,et al.(2002) Analysis of the reg1alpha and reg1beta gene transcripts in patients with fibrocalculous pancreatopathy. Southeast Asian J Trop Med Public Health. 33(2): 365-72.

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Keywords

REG1B Protein, Human, Recombinant (His) PSPS 2 regenerating islet-derived 1 beta PSPS2 REGL regenerating islet-derived 1 β REGH REGI-β PSPS-2 REGI-BETA recombinant recombinant-proteins proteins protein

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