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Nrf2 degrader 30是一种小分子PROTAC,能够抑制Nrf2的降解,从而增强Nrf2的活性。Nrf2(Nuclear factor erythroid 2-related factor 2)是一种关键的转录因子,调控细胞抗氧化反应和多种细胞保护机制。Nrf2的活性主要通过其与Keap1的相互作用来调节,Keap1作为E3泛素连接酶复合体的适配器,促进Nrf2的泛素化和蛋白酶体降解。
Nrf2 degrader 30是一种小分子PROTAC,能够抑制Nrf2的降解,从而增强Nrf2的活性。Nrf2(Nuclear factor erythroid 2-related factor 2)是一种关键的转录因子,调控细胞抗氧化反应和多种细胞保护机制。Nrf2的活性主要通过其与Keap1的相互作用来调节,Keap1作为E3泛素连接酶复合体的适配器,促进Nrf2的泛素化和蛋白酶体降解。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 5,560 | 现货 |
产品描述 | Nrf2 degrader 30 is a small molecule PROTAC that inhibits the degradation of Nrf2, thereby enhancing its activity. Nrf2 is a key transcription factor that regulates cellular antioxidant responses and various protective mechanisms. The activity of Nrf2 is primarily regulated by its interaction with Keap1, which serves as an E3 ubiquitin ligase complex adapter to promote Nrf2 ubiquitination and proteasomal degradation。 |
别名 | Compound 30 |
分子量 | 820.89 |
分子式 | C42H41FN8O7S |
CAS No. | 3025286-29-4 |
Smiles | O=C(C1=CN=CN1C)N2C3=CC=C(C=C3CC2)C=4N=C(SC4C)NC(=O)CC5=CC=C(F)C(OCCOCCNC6=CC=C7C(=O)N(CC7=C6)C8C(=O)NC(=O)CC8)=C5 |
密度 | no data available |
存储 | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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