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Aminopeptidase A Protein, Human, Recombinant (His)

产品编号 TMPY-00644

别名: APA, glutamyl aminopeptidase, ENPEP, gp160, CD249

Aminopeptidase A Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 107.2 kDa and the accession number is Q07075.

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Aminopeptidase A Protein, Human, Recombinant (His)

规格	价格/CNY		货期	数量
50 μg	￥ 3,820		5日内发货

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参考文献

生物活性	Measured by its ability to cleave the fluorogenic peptide substrate, Glu-7-amido-4-methyl coumarin (Glu-AMC). The specific activity is >2000 pmoles/min/μg.
产品描述	Aminopeptidase A Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 107.2 kDa and the accession number is Q07075.

种属	Human
表达系统	Baculovirus Insect Cells
标签	N-His
蛋白编号	Q07075
别名	APA, glutamyl aminopeptidase, ENPEP, gp160, CD249
蛋白构建	Human ENPEP (NP_001968.3) (Arg41-Gly957)
蛋白纯度	> 90 % as determined by SDS-PAGE
分子量	107.2 kDa (predicted)

内毒素	< 1.0 EU/μg of the protein as determined by the LAL method.
缓冲液	Supplied as sterile 20 mM, Tris 500 mM NaCl, 10% glycerol, pH 7.4.
复溶方法	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
存储	It is recommended to store the product under sterile conditions at -20°C to -80°C. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
运输方式	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
研究背景	ENPEP, also known as aminopeptidase A, is a member of the peptidase M1 family. Members of this family are involved in response to cadmium ion and proteolysis. They located in 6 components and are expressed in 26 plant structures. ENPEP is expressed by epithelial cells of the proximal tubule cells and the glomerulus of the nephron. It also can be detected in a variety of other tissues. ENPEP probably plays a role in regulating growth and differentiation of early B-lineage cells. It also may play a role in the catabolic pathway of the renin-angiotensin system. ENPEP is a zinc-dependent membrane-bound aminopeptidase that catalyzes the cleavage of glutamatic and aspartatic amino acid residues from the N-terminus of polypeptides. It degrades vasoconstricting angiotensin II into angiotensin III and therefore helps to regulate blood pressure.

参考文献

1. Speth RC,et al.(2008) The significance of brain aminopeptidases in the regulation of the actions of angiotensin peptides in the brain. Heart Fail Rev. 13(3):299-309. 2. Rose JE,et al.(2010) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Mol Med. 16(7-8):247-53. 3. Pérez I,et al.(2009) Increased APN/CD13 and acid aminopeptidase activities in head and neck squamous cell carcinoma. Head Neck. 31(10):1335-40.

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Keywords

Aminopeptidase A Protein, Human, Recombinant (His) APA glutamyl aminopeptidase CD-249 ENPEP CD 249 gp160 CD249 recombinant recombinant-proteins proteins protein

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