YB-0158

Name: YB-0158
Brand: TargetMol
SKU: T38519
Rating: 4.5 (1 reviews)

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产品编号 T38519Cas号 1144043-83-3

别名 YB-0158, Wnt pathway inhibitor 2

YB-0158 (Wnt pathway inhibitor 2) is a powerful peptidomimetic compound that effectively targets colorectal cancer stem cells (CSCs) by disrupting the interaction between Sam68 and Src proteins. This compound acts as a reverse-turn agent, inducing apoptosis in CRC cells and displaying strong anti-cancer activities.

YB-0158

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产品编号 T38519 别名 YB-0158, Wnt pathway inhibitor 2Cas号 1144043-83-3

规格	价格	库存	数量
25 mg	¥ 10,500	4-6周

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产品描述	YB-0158 (Wnt pathway inhibitor 2) is a powerful peptidomimetic compound that effectively targets colorectal cancer stem cells (CSCs) by disrupting the interaction between Sam68 and Src proteins. This compound acts as a reverse-turn agent, inducing apoptosis in CRC cells and displaying strong anti-cancer activities.
靶点活性	Wnt:6.2 μM (IC50)
体外活性	YB-0158 (0.2 μM and 0.5 μM; 48 hours) significantly increases apoptosis in CRC cells as represented by activated Caspase-3/7 detection assays[1]. YB-0158 (0.3 μM) similarly decreases CBP recruitment at the promoter of Wnt/beta-Catenin target genes LGR5 and MYC in HT29 cells, compared with DMSO control[1].
体内活性	YB-0158 displays an EC 50 (1.64 μM) in cultured MC38 cells. YB-0158 (100 mg/kg; IP; C57BL/6 mice bearing MC38 cells) shows no significant differences in primary tumor size in vivo treatments versus saline controls[2].
别名	YB-0158, Wnt pathway inhibitor 2