KIRA-7

Name: KIRA-7
Brand: TargetMol
SKU: T15664
Price: 263 USD
Availability: InStock
Rating: 4.5 (1 reviews)

产品编号 T15664Cas号 1937235-76-1

KIRA-7 is an imidazopyrazine compound. KIRA-7 has an anti-fibrotic effect. KIRA-7 binds the IRE1α kinase (IC50: 110 nM) to allosterically inhibit its RNase activity.

KIRA-7

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产品编号 T15664Cas号 1937235-76-1

KIRA-7 is an imidazopyrazine compound. KIRA-7 has an anti-fibrotic effect. KIRA-7 binds the IRE1α kinase (IC50: 110 nM) to allosterically inhibit its RNase activity.

规格	价格	库存
2 mg	¥ 2,870	5日内发货
25 mg	¥ 11,700	6-8周
50 mg	¥ 15,300	6-8周
100 mg	¥ 19,500	6-8周

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产品介绍

生物活性

产品描述	KIRA-7 is an imidazopyrazine compound. KIRA-7 has an anti-fibrotic effect. KIRA-7 binds the IRE1α kinase (IC50: 110 nM) to allosterically inhibit its RNase activity.
靶点活性	IRE1α kinase:110 nM
体外活性	In the alveolar epithelial cell line MLE12, KIRA-7 inhibits XBP1 splicing [1].
体内活性	After Bleomycin exposure, mRNA levels of BiP and CHOP are significantly elevated, and treatment of Bleomycin-exposed mice with KIRA-7 decreased these levels. KIRA-7 (5 mg/kg; intraperitoneal injection; daily for 14 days; C57BL6 mice) treatment causes decreased spliced XBP1 and ATF4, compared to bleomycin exposed mice treated with vehicle. mRNA levels of collagen 1A1 and fibronectin are both significantly decreased by KIRA-7 treatment [1].