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核受体 (Nuclear Receptors)

核受体 (Nuclear Receptors) 是一类负责感应类固醇、甲状腺激素、维生素等分子的蛋白质。核受体对动物具有特异性,因此不存在于原生生物、藻类、真菌或植物中。人类中有47个核受体。这些细胞内受体与其他蛋白质一起调节特定基因的表达,从而控制生物体的发育、稳态和代谢。核受体与其他类别受体的区别在于它们对基因组DNA的直接控制。因此,这些受体被归类为转录因子。核受体对基因表达的调节通常发生在配体存在的情况下。配体与核受体的结合导致构象变化,激活受体。结果是基因表达的上调或下调。核受体在胚胎发育和成体稳态中都起着关键作用。

  • PPAR alpha/PPARA Protein, Human, Recombinant (His)
    TMPY-06830
    PPAR alpha PPARA Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 31.36 kDa and the accession number is Q07869.
    • ¥ 3820
    现货
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  • PPAR gamma/PPARG Protein, Human, Recombinant (His & GST)
    TMPY-02575
    Peroxisome proliferator-activated receptor gamma (PPARG), a nuclear hormone receptor, plays a critical role in the lipid and glucose homeostasis, adipocyte differentiation, as well as intracellular insulin-signaling events. The peroxisome proliferator-activated receptor gamma (PPARgamma) regulates osteoblast and osteoclast differentiation, and is the molecular target of thiazolidinediones (TZDs), insulin sensitizers that enhance glucose utilization and adipocyte differentiation. Peroxisome proliferator-activated receptor gamma (PPARG) is a transcription factor involved in atherosclerosis and related diseases. Peroxisome proliferator-activated receptor gamma (PPARG) plays an important role in the pathogenesis and maintenance of essential hypertension (EH).The functional single nucleotide polymorphisms in peroxisome proliferator-activated receptor gamma (PPARG) gene were predicted to be correlated with the susceptibility of colorectal cancer (CRC).
    • ¥ 3820
    现货
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  • NR4A1 Protein, Human, Recombinant (His & Myc)
    TMPH-01796
    Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Plays a role in the vascular response to injury. NR4A1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 69.5 kDa and the accession number is P22736.
    • ¥ 1800
    20日内发货
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  • ER alpha Protein, Human, Recombinant (His)
    TMPJ-00762
    Estrogen Receptor is a major ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. Estrogen Receptor is composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but they also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.
    • ¥ 1170
    5日内发货
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  • NR1I2 Protein, Human, Recombinant (His & Myc & SUMO)
    TMPH-01793
    NR1I2 Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 69.8 kDa and the accession number is O75469.
    • ¥ 1320
    20日内发货
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  • RORA Protein, Human, Recombinant (His)
    TMPH-01791
    RORA Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 57.6 kDa and the accession number is P35398.
    • ¥ 1800
    20日内发货
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  • Androgen receptor Protein, Human, Recombinant (His & Myc & SUMO)
    TMPH-00932
    Androgen receptor Protein, Human, Recombinant (His & Myc & SUMO) is expressed in E. coli.
    • ¥ 1320
    20日内发货
    规格
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  • THRA Protein, Human, Recombinant (His)
    TMPH-02203
    Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.; Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action. THRA Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 58.9 kDa and the accession number is P10827.
    • ¥ 2290
    20日内发货
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  • LXR-alpha Protein, Human, Recombinant (His & Myc)
    TMPH-01819
    LXR-alpha Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 53.1 kDa and the accession number is Q13133.
    • ¥ 1320
    20日内发货
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  • NR2F6 Protein, Human, Recombinant (His & Myc)
    TMPH-01794
    NR2F6 Protein, Human, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-6xHis-Myc tag. The predicted molecular weight is 47.0 kDa and the accession number is P10588.
    • ¥ 2960
    20日内发货
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  • RORC Protein, Human, Recombinant (His & SUMO)
    TMPH-01792
    RORC Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 74.2 kDa and the accession number is P51449.
    • ¥ 1320
    20日内发货
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  • THRB Protein, Human, Recombinant (His)
    TMPY-06821
    Thyroid hormone receptor beta (THRB), also known as TRbeta and NR1A2, belongs to the nuclear hormone receptor family. Featuring an N-terminal transactivation domain, a central DNA-binding domain, and a hormone ligand-binding domain, THRB isoform 1 2 expression localizes predominately to the liver and pituitary, respectively. THRB regulates the feedback of T3-dependent thyrotropin-stimulating hormone (TSH) transcription in the pituitary by binding to thyroid hormone (TH) response elements present on promoters of TH-responsive genes. Located on chromosome 3p24, THRB gene mutation has been linked to autosomal dominant resistance to TH (RTH), which is characterized by goiter and elevated levels of T3, T4, and TSH. THRB is a known pharmacological target for the treatment of non-alcoholic steatohepatitis (NASH). THRB may be a target for future cancer therapies since its knockdown enhanced the viability of endometrial cancer cells and activated the mTOR-4EBP1 eIF4G pathway.
    • ¥ 3820
    5日内发货
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  • ER beta Protein, Human, Recombinant (E. coli, His)
    TMPH-01304
    Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1 ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.; Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability. ER beta Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 39.8 kDa and the accession number is Q92731.
    • ¥ 1320
    20日内发货
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  • NR4A2 Protein, Human, Recombinant (His)
    TMPH-01797
    Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. NR4A2 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 68.6 kDa and the accession number is P43354.
    • ¥ 2170
    20日内发货
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  • Vitamin D Receptor/VDR Protein, Human, Recombinant (His)
    TMPY-02706
    Vitamin D Receptor VDR Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 50 kDa and the accession number is P11473.
    • ¥ 3170
    5日内发货
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  • ER beta Protein, Human, Recombinant (His)
    TMPH-01305
    Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1 ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner.; Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability. ER beta Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 61.1 kDa and the accession number is Q92731.
    • ¥ 1470
    20日内发货
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  • NR2F6 Protein, Human, Recombinant (His & SUMO)
    TMPH-01795
    NR2F6 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 59.0 kDa and the accession number is P10588.
    • ¥ 1800
    20日内发货
    规格
    数量
  • THRB Protein, Human, Recombinant (His & SUMO)
    TMPH-02204
    Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
    • ¥ 1320
    20日内发货
    规格
    数量
  • PPAR gamma Protein, Mouse, Recombinant (His)
    TMPH-02827
    PPAR gamma Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 63.3 kDa and the accession number is P37238.
    • ¥ 1800
    20日内发货
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  • PPAR gamma Protein, Xenopus laevis, Recombinant (His)
    TMPH-03711
    Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.
    • ¥ 2290
    20日内发货
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  • Ppard Protein, Human, Recombinant (His)
    TMPH-03755
    Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.
    • ¥ 1800
    20日内发货
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  • Vitamin D Receptor/VDR Protein, Mouse, Recombinant (His)
    TMPY-02987
    Vitamin D Receptor VDR Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 49.28 kDa and the accession number is P48281.
    • ¥ 4460
    5日内发货
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  • PPAR alpha/PPARA Protein, Mouse, Recombinant (His)
    TMPY-06837
    PPAR alpha PPARA Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 31.49 kDa and the accession number is P23204.
    • ¥ 3820
    5日内发货
    规格
    数量