IV-361

Name: IV-361
Brand: TargetMol
SKU: T39456
Price: 1960 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T39456Cas号 2055741-39-2

IV-361, an orally active and selective CDK7 inhibitor with a Ki value of less than or equal to 50 nM, demonstrates potent anti-cancer activity (US20190256531A1).

IV-361

还可以

产品编号 T39456Cas号 2055741-39-2

IV-361, an orally active and selective CDK7 inhibitor with a Ki value of less than or equal to 50 nM, demonstrates potent anti-cancer activity (US20190256531A1).

规格	价格	库存	数量
25 mg	¥ 13,100	6-8周

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产品介绍

生物活性

产品描述	IV-361, an orally active and selective CDK7 inhibitor with a Ki value of less than or equal to 50 nM, demonstrates potent anti-cancer activity (US20190256531A1).
靶点活性	CDK7:≤50 nM (Ki), CDK2:≥1000 nM (Ki)
体外活性	IV-361 has less inhibition on CDK2 (K i ≥1000 nM) or PLK1 (K i ≥5000 nM)[1]. IV-361 exhibits excellent IL-2 and IL-17 production inhibitory activity (all IC 50 ≤100 nM) in periphery blood mononuclear cell (PBMC)[1]. IV-361 exhibits excellent HCT-116 cell growth inhibitory activity (GI 50 ≤100 nM)[1].
体内活性	IV-361 (25 mg/kg/day; orally) exhibits 46% or more rate of suppression of tumor volume in female BALB nude mice with HCT-116[1].