DHMEQ racemate

Name: DHMEQ racemate
Brand: TargetMol
SKU: T11018
Price: 476 USD
Availability: InStock
Rating: 4.5 (1 reviews)

产品编号 T11018Cas号 287194-38-1

别名 rel-DHMEQ

DHMEQ racemate is an NF-κB inhibitor. The activity of DHMEQ racemate is lower than (-)-DHMEQ.

纯度: 无数据

产品编号 T11018 别名 rel-DHMEQCas号 287194-38-1

DHMEQ racemate is an NF-κB inhibitor. The activity of DHMEQ racemate is lower than (-)-DHMEQ.

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产品介绍

生物活性

产品描述	DHMEQ racemate is an NF-κB inhibitor. The activity of DHMEQ racemate is lower than (-)-DHMEQ.
体外活性	DHMEQ racemate (DHM3EQ) and (-)-DHMEQ (DHM2EQ) inhibit TNF-a-induced NF-kB activation. (-)-DHMEQ is more effective and less toxic than DHMEQ racemate.
体内活性	The anti-arthritis effect of (-)-DHMEQ (DHM2EQ) and DHMEQ racemate (DHM3EQ) on type II collagen-induced arthritis in DBA1/J mice was studied. Because of its pathological similarity to human rheumatoid arthritis, this animal model is widely used to evaluate anti-rheumatic drugs. Cause arthritis and score it. (-)-DHMEQ significantly inhibited type II collagen-induced arthritis in mice, while DHMEQ racemates tended to only slightly inhibit it.
别名	rel-DHMEQ

化学信息

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 32 mg/mL (122.50 mM)

溶液配制表

DMSO