6-Hydroxyflavanone, extracted from the leaves of Acorus calamus, exhibits anti-inflammatory and anti-neuropathic pain activity by targeting cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), as well as opioid and GABA-A receptors. 6-Hydroxyflavanone has anti-injury sensory properties in a streptozotocin-induced diabetic neuropathy model. in a streptozotocin-induced diabetic neuropathy model with anti-injury sensory properties.

Androgen receptor:3.3 µM

6-Hydroxyflavanone((6-HF)(5、30和60 mg/kg)显著抑制了COX-2和5-LOX酶。它在热板镇痛计中大幅减少了热性痛觉，并且在啮齿动物模型中显著减轻了由卡拉胶引起的爪肿胀。研究者发现，6-HF在链脲佐菌素诱导的糖尿病神经病变（DIN）模型中表现出抗痛觉属性。根据这项研究的发现，6-HF具备减少糖尿病引起的炎症及发挥抗痛觉作用的能力。